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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Sonodynamic cancer therapy by a nickel ferrite/carbon nanocomposite on melanoma tumor: In vitro and in vivo studies
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Sonodynamic cancer therapy by a nickel ferrite/carbon nanocomposite on melanoma tumor: In vitro and in vivo studies

机译：铁氧体/碳纳米复合材料对黑素瘤肿瘤的声动力学癌症治疗：体内和体外研究

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摘要

Reactive oxygen species (ROS)-mediated cancer therapy using light or ultrasound (US) has been widely approached as a non-invasive and inspiring alternative treatment. Sonodynamic therapy (SDT), a non-invasive therapeutic modality of cancer, is an outcome of low-intensity US effect on cancer cells using a sonosensitizer, which results in heat and ROS production followed by cell death. The aim of this study was synthesis, characterization and cancer SDT application of a nickel ferrite/carbon nanocomposite (NiFe2O4/C), as a sonosensitizer. SDT was carried out by applying a 1.0-MHz US radiation at 1.0 W cm(-2) of power density and 100% pulse ratio for 60 s. A significant C540 (B16/F10) cell killing was observed in vitro due to ROS production of 100 mu g mL(-1) of NiFe2O4/C upon SDT. In addition, SDT of melanoma cancer in a mouse model using intratumorally injected NiFe2O4/C of 100 mu g mL(-1) produced remarkable efficacious recovery in the tumor and significant necrosis (up to 60%) in histological assessments, while injection of NiFe2O4/C or US irradiation alone induced no healing effect. Therefore, SDT using NiFe2O4/C attained success in destroying melanoma cancer and can be developed and introduced as an alternative treatment strategy for melanoma cancer. In furtherance of SDT, magnetic resonance (MR) imaging (1.5 T) in an agarose phantom indicated the effectiveness of NiFe2O4/C as a negative contrast agent in transverse relaxation time-weighted imaging with a corresponding relaxation rate (r(2)) of 78.9 mmol L-1 s(-1).The results confirmed the applicability of the nanocomposite as a theranostics agent for simultaneous SDT and MR imaging.
机译：使用光或超声（US）的活性氧（ROS）介导的癌症治疗已被广泛用作无创且启发性的替代疗法。声波动力疗法（SDT）是一种非侵入性的癌症治疗方法，是使用声敏剂对癌细胞进行低强度US效应的结果，其导致热量和ROS产生，然后导致细胞死亡。这项研究的目的是镍铁氧体/碳纳米复合材料（NiFe2O4 / C）作为声敏剂的合成，表征和癌症SDT应用。通过在1.0 W cm（-2）的功率密度和100％的脉冲比下施加1.0 MHz的US辐射60 s来进行SDT。在SDT上，由于ROS产生了100μg mL（-1）的NiFe2O4 / C，在体外观察到了严重的C540（B16 / F10）细胞杀伤。此外，在小鼠模型中，瘤内注射NiFe2O4 / C为100μg mL（-1）时，黑色素瘤癌症的SDT在肿瘤组织学评估中产生了显着的有效恢复，并且在组织学评估中产生了明显的坏死（高达60％），同时注射了NiFe2O4单独的/ C或US照射不会引起愈合效果。因此，使用NiFe2O4 / C的SDT在破坏黑素瘤癌症方面取得了成功，可以作为黑素瘤癌症的替代治疗策略进行开发和引入。为了促进SDT，琼脂糖体模中的磁共振（MR）成像（1.5 T）表明，NiFe2O4 / C作为横向弛豫时间加权成像中的负造影剂的有效性，相应的弛豫率（r（2））为78.9 mmol L-1 s（-1）。结果证实了纳米复合材料作为治疗剂的适用性，可同时进行SDT和MR成像。

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