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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >PDT with PPIX absorption peaks adjusted wavelengths: Safety and efficacy of a new irradiation procedure for actinic keratoses on the head
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PDT with PPIX absorption peaks adjusted wavelengths: Safety and efficacy of a new irradiation procedure for actinic keratoses on the head

机译：具有PPIX吸收峰的PDT调整了波长：头部光化性角化病的新照射程序的安全性和有效性

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Background: Daylight photodynamic therapy (dl-PDT) is an effective and almost painless treatment for patients with actinic keratoses (AKs) but carries important limitations due to seasonal conditions. PDT with Protoporphyrin IX (PPIX) peaks adjusted wavelengths might overcome these shortcomings. The aim of this study was to determine safety and efficacy of ALA-PDT with a new irradiation procedure.Methods: Patients with AKs on the head received ALA-PDT with a new irradiation device. Emitted wavelengths are adjusted to PPIX absorption peaks (457 nm, 523 nm, 593 nm, 631 nm; 20.000 lx). PDT protocol was adapted for both 1 h of incubation and irradiation time. Outcome was assessed by AK area and severity index (AKASI) and lesion count (LC) prior to and 3 months after treatment. Safety was monitored by blood pressure and pulse measurements throughout treatment. Pain was determined by use of a visual analog scale (VAS).Results: Overall, 39 patients were included and showed a significant AKASI reduction (P < 0.0001) 3 months after PDT (mean AKASI of 2 +/- 1.6) compared to baseline (5.2 +/- 1.9). Mean reduction rate was 63.7% +/- 24.2%, accordingly. Eight patients (20.5%) achieved AKASI 100, eleven (28.2%) AKASI 75 and thirty (76.9%) AKASI 50, respectively. There were no significant changes in blood pressure and pulse throughout treatment. Median VAS for pain during irradiation was 0 (0-1), 1 (0-1) and 0 (0-1) at the beginning, in the meantime and at the end, respectively.Conclusions: ALA-PDT with a new irradiation procedure is a safe, effective and almost painless treatment option for patients with AKs on the head.
机译：背景：日光动力疗法（dl-PDT）对于光化性角化病（AKs）患者是一种有效且几乎无痛的疗法，但由于季节原因，其存在重要局限性。具有原卟啉IX（PPIX）峰调整波长的PDT可以克服这些缺点。这项研究的目的是通过一种新的辐照程序确定ALA-PDT的安全性和有效性。方法：头颅AKs的患者采用一种新的辐照设备接受ALA-PDT。将发射的波长调整为PPIX吸收峰（457 nm，523 nm，593 nm，631 nm； 20.000 lx）。 PDT协议适用于孵育1小时和照射时间。治疗前和治疗后3个月，通过AK面积和严重程度指数（AKASI）和病变计数（LC）评估结果。在整个治疗过程中，通过血压和脉搏测量监测安全性。结果：总体上，纳入39例患者，PDT后3个月AKASI显着降低（P <0.0001）（基线平均AKASI为2 +/- 1.6）。 （5.2 +/- 1.9）。因此，平均降低率为63.7％+/- 24.2％。八名患者（20.5％）达到AKASI 100，十一名（28.2％）AKASI 75和三十名（76.9％）AKASI 50。整个治疗过程中血压和脉搏无明显变化。照射期间疼痛的VAS中位值在开始，同时和结束时分别为0（0-1），1（0-1）和0（0-1）。结论：新照射ALA-PDT对于头部AK的患者，此方法是一种安全，有效且几乎无痛的治疗选择。

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