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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Antimicrobial photodynamic therapy reduces adhesion capacity and biofilm formation of Candida albicans from induced oral candidiasis in mice
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Antimicrobial photodynamic therapy reduces adhesion capacity and biofilm formation of Candida albicans from induced oral candidiasis in mice

机译：抗菌光动力疗法可降低小鼠口腔念珠菌病引起的白色念珠菌的粘附能力和生物膜形成

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Background: : Antimicrobial photodynamic therapy (aPDT) has been considered an alternative therapeutic modality for the treatment of Candida infections. However, most studies are focused mainly on microorganism's inactivation efficiency. Here, we evaluated the efficacy of aPDT mediated by chloro-aluminum phthalocyanine encapsulated in cationic nanoemulsions (ClAlP-NE) to treat oral candidiasis in vivo and its effect on the adhesion and biofilm formation of Candida albicans.Methods: : For this, mice were immunosuppressed and inoculated with C. albicans to produce oral candidiasis. aPDT and Nystatin were applied for 5 successive sessions. Next, the microbiological evaluation was determined (CFU/ml) and the analyses of virulence factors (adhesion capacity and biofilm formation) were performed. Data were analyzed by Two-way ANOVA (alpha = 0.05).Results: : aPDT was as effective as Nystatin reducing 1.4 and 2.0 log(10) of the cell viability (p <= 0.0001), respectively. Both treatments reduced the adhesion capacity and biofilm formation of C. albicans (p <= 0.0001)Conclusion: : ClAlP-NE-mediated aPDT was effective in reducing the virulence factors of C. albicans and also to treat induced oral candidiasis in mice.
机译：背景：抗菌素光动力疗法（aPDT）被认为是治疗念珠菌感染的替代疗法。但是，大多数研究主要集中在微生物的灭活效率上。在这里，我们评估了封装在阳离子纳米乳剂（ClAlP-NE）中的氯铝酞菁介导的aPDT在体内治疗口腔念珠菌病的功效及其对白色念珠菌粘附和生物膜形成的影响。免疫抑制并接种白色念珠菌以产生口腔念珠菌病。 aPDT和制霉菌素已连续5次使用。接下来，确定微生物评价（CFU / ml），并进行毒力因子（粘附能力和生物膜形成）的分析。通过双向方差分析（alpha = 0.05）分析数据。结果：aPDT与制霉菌素一样有效，分别降低了细胞活力的1.4和2.0 log（10）（p <= 0.0001）。两种处理均降低了白色念珠菌的粘附能力和生物膜形成（p <= 0.0001）结论：ClAlP-NE介导的aPDT可以有效降低白色念珠菌的致病因子，还可以治疗小鼠诱导的口腔念珠菌病。

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