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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Effect of ultrasonic activation on the efficacy of antimicrobial photodynamic therapy: Evaluation of penetration depth of photosensitizer and elimination of Enterococcus faecalis biofilms
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Effect of ultrasonic activation on the efficacy of antimicrobial photodynamic therapy: Evaluation of penetration depth of photosensitizer and elimination of Enterococcus faecalis biofilms

机译：超声活化对抗菌光动力疗法疗效的影响：光敏剂渗透深度和粪肠球菌生物膜清除的评估

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Background: This study aimed to assess the effect of ultrasonic activation of photosensitizer on the efficacy of Antimicrobial Photodynamic Therapy (aPDT) against Enterococcus faecalis and penetration depth of photosensitizer.Materials and methods: In this ex vivo study, mature microbial biofilm of E. faecalis was formed in the root canals of 58 single-rooted single-canal mandibular incisors following their decoronation. The roots were longitudinally sectioned by a diamond disc and split into halves by a chisel. The E. faecalis biofilm was quantified and the penetration depth of photosensitizer was determined by the microbial viability assay and stereomicroscopic analysis in the following three study groups: (1) Ultrasonically activated 5.25% sodium hypochlorite (NaOCl) for 20 s, (2) aPDT using methylene blue (MB) plus 660 nm diode laser with 150 mW power for 1 minute, and (3) ultrasonically activated MB for 20 s followed by aPDT as in group 2. Independent sample t test and one way ANOVA were used to compare the dye penetration depth and microbial load, respectively in the apical and coronal regions among the groups.Results: The penetration depth of photosensitizer in group 3 was significantly greater than that in group 2 (P < 0.05). The E. faecalis count in all three experimental groups was significantly lower than that in the control group (P < 0.05). Groups 1 and 3 were significantly superior to group 2 in terms of reduction in microbial count but the difference between groups 1 and 3 was not significant (P > 0.05).Conclusion: Ultrasonic activation of photosensitizer in aPDT increases the penetration depth of photosensitizer into the dentinal tubules and enhances its antibacterial activity.Highlight Ultrasonic activation of photosensitizer in aPDT enhances its penetration depth into dentinal tubules and increases antibacterial efficacy.There was no significant difference between antibacterial effects of aPDT + ultrasonic and ultrasonic activated NaOCl.
机译：背景：本研究旨在评估光敏剂的超声活化对粪便肠球菌的抗菌光动力疗法（aPDT）的功效和光敏剂的渗透深度的作用。根除后在58根单根单管下颌切牙的根管中形成。根由金刚石盘纵向切开，并用凿子分成两半。在以下三个研究组中，对粪肠球菌的生物膜进行了定量，并通过微生物活力测定和立体显微镜分析确定了光敏剂的渗透深度：（1）超声活化5.25％次氯酸钠（NaOCl）20 s，（2）aPDT使用亚甲基蓝（MB）和660 nm二极管激光器，功率为150 mW持续1分钟，（3）超声激活MB持续20 s，然后进行第2组中的aPDT。使用独立样本t检验和一种方差分析比较结果：3组光敏剂的渗透深度明显大于2组（P <0.05）。三个实验组的粪肠球菌计数均显着低于对照组（P <0.05）。在减少微生物数量方面，第1和第3组明显优于第2组，但第1和第3组之间的差异不显着（P> 0.05）。牙本质小管并增强其抗菌活性。aPDT中光敏剂的高强度超声活化可增加其在牙本质小管中的渗透深度并提高抗菌效果。aPDT +超声波和超声活化的NaOCl的抗菌作用之间无显着差异。

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