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Comparison of different laser-based photochemical systems for periodontal treatment

机译：比较不同的基于激光的光化学系统进行牙周治疗

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Purpose: The main aim in periodontitis treatment is to remove supragingival and subgingival biofilm. Mechanical treatment to eliminate pathogenic bacteria is limited by morphological conditions on the root surface. This study assessed the antibacterial effectiveness of different laser-based photochemical systems, particularly a novel curcumin-based option.Methods: Ninety-one titanium bars were inoculated with an artificial biofilm of common pathogenic periodontal bacteria and inserted into an artificial periodontal pocket model. The following groups (n = 13) were tested: 1, curcumin solution plus SLB laser irradiation (C + L; 445 nm, 0.6 W, 25% duty cycle, 100 Hz, 10 s); 2, curcumin solution (Cur); 3, dimethyl sulfoxide solution (DMSO); 4, SiroLaser Blue (SLB) - laser irradiation (445 nm, 0.6 W, 25% duty cycle, 100 Hz, 10 s); 5, antimicrobial photodynamic therapy (aPDT); 6, antimicrobial photothermal therapy (aPTT); 7, control. The samples were stored in Eppendorf tubes and analyzed microbiologically using quantitative real-time polymerase chain reaction (PCR). The main parameter for analyzing group differences was the total bacterial load. Statistical analysis was performed with nonparametric methods.Results: Statistically significant reductions in bacterial count were observed in all experimental groups (p < 0.05). The mean percentage reductions were as follows: SLB, 95.03%; aPDT, 83.91%; DMSO, 95.69%; C + L, 97.15%. No statistically significant differences in bacteria reduction were observed for laser alone (SLB), DMSO, or curcumin with or without additional laser irradiation.Conclusions: The greatest antibacterial efficacy was observed in samples treated with aPTT. Using curcumin as a photosensitizing agent for 445 nm laser irradiation did not result in improved antibacterial effectiveness in comparison with laser alone.
机译：目的：治疗牙周炎的主要目的是去除龈上和龈下生物膜。根部表面的形态学条件限制了消除病原细菌的机械处理。这项研究评估了不同的基于激光的光化学系统的抗菌效果，特别是基于姜黄素的新型方法。方法：将九十一个钛棒接种常见病原性牙周细菌的人工生物膜，然后插入人工牙周袋模型中。测试了以下组（n = 13）：1，姜黄素溶液加SLB激光照射（C + L； 445 nm，0.6 W，25％占空比，100 Hz，10 s）； 2，姜黄素溶液（Cur）； 3，二甲基亚砜溶液（DMSO）； 4，SiroLaser Blue（SLB）-激光照射（445 nm，0.6 W，25％占空比，100 Hz，10 s）; 5，抗菌光动力疗法（aPDT）； 6，抗菌素光热疗法（aPTT）； 7，控制。将样品存储在Eppendorf管中，并使用定量实时聚合酶链反应（PCR）进行微生物学分析。分析组差异的主要参数是总细菌负荷。结果：在所有实验组中观察到细菌计数的统计学显着降低（p <0.05）。平均减少百分比如下：SLB，95.03％； aPDT，83.91％；二甲基亚砜，95.69％； C + L，97.15％。在单独的激光（SLB），DMSO或姜黄素（有或没有额外的激光照射）下，细菌减少没有统计学上的显着差异。结论：用aPTT处理的样品观察到最大的抗菌功效。与仅使用激光相比，将姜黄素用作445 nm激光照射的光敏剂并没有提高抗菌效果。

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