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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Shear bond strength, adhesive remnant index, and anti-biofilm effects of a photoexcited modified orthodontic adhesive containing curcumin doped poly lactic-co-glycolic acid nanoparticles: An ex-vivo biofilm model of S. mutans on the enamel slab bonded brackets
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Shear bond strength, adhesive remnant index, and anti-biofilm effects of a photoexcited modified orthodontic adhesive containing curcumin doped poly lactic-co-glycolic acid nanoparticles: An ex-vivo biofilm model of S. mutans on the enamel slab bonded brackets

机译：含有姜黄素掺杂的聚乳酸共聚乙酸纳米粒子的光透明的修饰正畸粘合剂的剪切粘合强度，粘合剂残留指数和抗生物膜效应：搪瓷板粘结支架上的S. mutans的前体内生物膜模型

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Background: Potential complications during fixed orthodontic procedures are white spot lesions (WSLs) and tooth decay. This study evaluated the anti-biofilm activity of an orthodontic adhesive (OA) incorporating curcumin (Cur) doped Poly lactic-co-glycolic acid nanoparticles (Cur-PLGA-NPs), which can have the highest concentration of Cur-PLGA-NPs and shear bond strength (SBS) value simultaneously, against cariogenic bacteria i.e., Streptococcus mutans.Materials and methods: Following synthesis and confirmation of Cur-PLGA-NPs, SBS and adhesive remnant index (ARI) of the modified orthodontic adhesives (MOA) containing Cur-PLGA-NPs (3, 5, 7, and 10 % wt.) were measured using universal testing machine and stereomicroscope, respectively. After artificial aging (continuously rinsed up to 180 days), the residual anti-biofilm ability of MOA which can have the highest concentration of Cur-PLGA-NPs and SBS value simultaneously were determined by anti-biofilm assay following photoexcited enamel slab bonded brackets by MOA containing Cur-PLGA-NPs against S. mutans biofilms using crystal violet assay.Results: Adhesive with 7 % wt. Cur-PLGA-NPs revealed the highest concentration of Cur-PLGA-NPs and SBS value (16.19 +/- 2.69 MPa, P 0.05) simultaneously. No statistically significant difference in ARI scores was observed between the MOA and control (Transbond XT without the Cur-PLGA-NPs). On days 15, 30, 60, 90 and 120 there was a considerable decrease in optical density (OD) of preformed S. mutans biofilms on photoexcited enamel slab bonded brackets using MOA containing 7 % wt. Cur-PLGA-NPs, to 94.1 %, 79.6 %, 69.6 %, 69.4 %, and, 55.1 % respectively in comparison to the control group (all, P 0.05). From days 150 onwards, microbial biofilm formation was progressively increased on enamel slab bonded brackets using MOA containing 7 % wt. Cur-PLGA-NPs compared to the control group (OA). Although chlorhexidine (2 %; as positive control) showed significant activity against pre-formed S. mutans biofilms on enamel slab bonded brackets using OA (99.1 % biofilm reduction; P = 0.001), its activity was slightly higher but not significant than photoexcited enamel slab bonded brackets using MOA containing 7 % wt. Cur-PLGA-NPs on the days 15 and 30 (both, P 0.05).Conclusions: The 7 % wt. Cur-PLGA-NPs can serve as an orthodontic adhesive antimicrobial additive as exposure to blue laser provides an acceptable antimicrobial effect against cariogenic bacteria for a considerable time.
机译：背景：固定正畸手术期间的潜在并发症是白斑病变（WSL）和蛀牙。该研究评估了掺入姜黄素（Cur）掺杂的聚乳酸碳酸纳米粒子（Cur-PLGA-NPS）的正畸粘合剂（OA）的抗生物膜活性，其可具有最高的Cur-PLGA-NPS和同时剪切粘合强度（SBS）值，对抗致癌细菌，即链球菌。材料和方法：在合成和确认含有Cur的改性正畸粘合剂（MOA）的Cur-PLGA-NPS，SBS和粘合剂残留指数（ARI）之后使用通用测试机和立体显微镜测量-PLGA-NPS（3,5,7和10％wt。）。在人工老化（连续冲洗至180天）后，通过抗生物膜木板键合支架通过抗生物膜测定同时测定可具有最高浓度的Cur-PLGA-NPS和SBS值的MOA的残留抗生物膜能力。使用晶体紫色捕获的MOA对抗S. mutans生物膜。结果：粘合剂为7％wt。 Cur-PLGA-NPS同时显示出最高浓度的Cur-PLGA-NPS和SBS值（16.19 +/- 2.69MPa，P <0.05）。在MOA和对照之间没有观察到ARI评分的统计学上显着差异（没有CUR-PLGA-NPS的roborbond XT）。在第15,30,60,90和120时，使用含有7％wt的MOA在光屏蔽的搪瓷板坯键合支架上存在显着的光密度（OD）的光密度（OD）的显着降低。与对照组相比，Cur-PLGA-NPS，分别为94.1％，79.6％，69.6％，69.4％，55.1％（全部，P <0.05）。从第150天开始，使用含有7％wt的MOA的MOA在搪瓷板键合支架上逐渐增加微生物生物膜形成。与对照组（OA）相比的Cur-PLGA-NPS。虽然氯己定（2％;阳性对照）显示使用OA的牙釉质板坯键合支架上预先形成的S. mutans生物膜的显着活性（99.1％的生物膜减少; p = 0.001），其活性略高，但不如光透镜釉板坯键合支架使用含有7％wt的MOA。第15天和第30天（两者，P> 0.05）。结论：7％wt。 Cur-PLGA-NPS可以用作正畸粘合剂抗微生物添加剂，因为暴露于蓝色激光器为致癌细菌提供了可接受的抗微生物作用，可实现相当长的时间。

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