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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Effectiveness of antimicrobial photodynamic therapy in restoring clinical, microbial, proinflammatory cytokines and pain scores in adolescent patients having generalized gingivitis and undergoing fixed orthodontic treatment
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Effectiveness of antimicrobial photodynamic therapy in restoring clinical, microbial, proinflammatory cytokines and pain scores in adolescent patients having generalized gingivitis and undergoing fixed orthodontic treatment

机译：抗菌光动力治疗在透明牙龈炎的青少年患者恢复临床，微生物，促炎细胞因子和疼痛评分中的有效性，致癌正畸治疗

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Background: The aim of the present study was to evaluate the effectiveness of photodynamic therapy (PDT) on clinical gingival inflammatory parameters, bacterial load, proinflammatory cytokine status, and pain scores in adolescent patients undergoing fixed orthodontic treatment with gingivitis.Methods: Thirty adolescent undergoing fixed orthodontic treatment with gingivitis were randomly divided into two groups: Group A - patients undergoing dental scaling (DS) with adjunctive photodynamic therapy (PDT) and Group B-DS alone. Clinical gingival parameters including plaque scores, (PS), bleeding on probing (BOP) and probing depth (PD) were assessed. Visual analogue scale (VAS) and McGill Pain Questionnaire (MPQ) were used to report the values of present pain intensity. Crevicular fluid was sampled to quantify the levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha using enzyme-linked immunosorbent assay. The total bacterial counts for Porphyromonas gingivalis (P. gingivalis) and Tannerella forsythia (T. forsythia) were assessed. All examinations were performed at baseline, 1 week and 4 weeks.Results: Both the treatment regimens reported statistically significant reduction in PS and BOP (p 0.05). However, no significant difference was observed in PS and PD values when Group B was compared with Group A (p 0.05). There was a statistically significant reduction noted for BOP in Group B when compared to Group A (p 0.05). There was a statistically significant reduction in the microbial counts of T. forsythia in Group A when compared to Group B at week-1 (p 0.05). During the 4-week follow-up, the counts for T. forsythia significantly increased. No significant changes could be seen in either of the pain scores in both the groups (p 0.05). Both groups showed statistically significant reduction in the IL-6 and TNF-alpha levels. However, IL-6 was significantly reduced at 1 week, while TNF-alpha significantly reduced at 4 weeks of follow up among the participants in Group B.Conclusion: PDT has a positive effect in significantly reducing the periodontal microbial load in established gingivitis in adolescent patients undergoing fixed orthodontic treatment.
机译：背景：本研究的目的是评估光动力治疗（PDT）对临床牙龈炎性参数，细菌荷载，促炎细胞因子状态和疼痛评分的有效性，所述青春期患者与Gingivitis治疗固定的正畸治疗。方法：三十间青少年正在进行中固定与牙龈炎的正畸治疗随机分为两组：A组 - 接受牙科缩放（DS）的患者，辅助光动力治疗（PDT）和单独组B-DS。评估包括斑块评分（PS），在探测（BOP）上出血和探测深度（PD）的临床牙龈参数。视觉模拟量表（VAS）和McGill疼痛问卷（MPQ）用于报告目前疼痛强度的值。使用酶联免疫吸附测定法对沟槽液进行取样以量化白细胞介素（IL）-6和肿瘤坏死因子（TNF） - α的水平。评估了卟啉孢子术（P.Gingivalis）和Tannerella连翘（T.fosythia）的总细菌计数。所有检查均在基线，1周和4周内进行。结果：治疗方案均报告统计上显着降低PS和BOP（P <0.05）。然而，当B组与A组（P> 0.05）进行比较时，在B组（P> 0.05）中，在PS和Pd值中没有观察到显着差异。与A组（P <0.05）相比，B组中BOP的统计学上显着减少了（P <0.05）。与第1周的B组（P <0.05）相比，A组A中T.连翘的微生物计数有统计学显着降低（P <0.05）。在为期4周的随访期间，T.连翘的计数显着增加。在组中的任何一个疼痛评分中都没有显着改变（P> 0.05）。两组在IL-6和TNF-α水平上表现出统计学显着降低。然而，IL-6在1周内显着减少，而TNF-α在B组参与者中的4周内显着减少。结论：PDT在显着降低了在青少年的牙周炎中的牙周微生物载体显着降低了阳性效果患者接受固定的正畸治疗。

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