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Modified nanoscale metal organic framework-based nanoplatforms in photodynamic therapy and further applications

机译：基于纳米级金属有机骨架的基于光动力治疗和进一步应用的纳米载体

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摘要

Photodynamic therapy (PDT) has emerged as a modality in cancer treatment because it is less invasive and highly selective compared with conventional chemotherapy and radiation therapy. Nanoscale metal organic frameworks (nMOFs) have exhibited great potential for use in constructing nanoplatforms for improved PDT because of their unique structural advantages such as large surface areas, high porosities, tunable compositions and various other modifications. The large majority of current nMOF-based systems employ specific modifying groups to overcome the deficiencies previously observed when using older nMOFs in PDT. In this review, we summarize modifications to these systems such as enhancing singlet oxygen generation by introducing photoactive agents, alleviating tumor hypoxia and engineering active targeting abilities. The applications of MOF-based nanoparticles in synergistic cancer therapies that include PDT, as well as in theranostics are also discussed. Finally, we discuss some of the challenges faced in this field and the future prospects for the use of nMOFs in PDT.
机译：光动力治疗（PDT）被出现为癌症治疗的态势，因为与常规化疗和放射治疗相比，它的侵入性和高度选择性较少。纳米级金属有机框架（NMOFS）由于其独特的结构优势，如大型表面积，高孔隙率，可调谐组合物和各种其他修改，纳米级金属有机框架（NMOFS）呈现出巨大的用途。基于NMOF的大多数基于NMOF的系统采用特定的修饰组来克服在PDT中使用较旧的NMOF时之前观察到的缺陷。在本文中，我们总结了对这些系统的修改，例如通过引入光活性剂来增强单次氧生成，减轻肿瘤缺氧和工程活性靶向能力。还讨论了基于MOF基纳米颗粒在包括PDT以及治疗器中的协同癌疗法中的应用。最后，我们讨论了这一领域所面临的一些挑战以及在PDT中使用NMOFS的未来前景。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2020年第12期|102026.1-102026.11|共11页
  • 作者

    Gao Dongruo; Gao Ying; Shen Jie; Wang Qiwen;

  • 作者单位

    Zhejiang Univ City Coll Sch Med Dept Pharm Hangzhou 310015 Peoples R China|Zhejiang Univ Coll Chem & Biol Engn Hangzhou 310027 Zhejiang Peoples R China;

    Zhejiang Univ City Coll Sch Med Dept Pharm Hangzhou 310015 Peoples R China|Zhejiang Univ Coll Pharmaceut Sci Dept Pharmaceut Hangzhou 310058 Peoples R China;

    Zhejiang Univ City Coll Sch Med Dept Pharm Hangzhou 310015 Peoples R China;

    Zhejiang Univ Affiliated Hosp 1 Dept Cardiol Sch Med Hangzhou 310003 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    PDT; nMOFs; Modification; Cancer; Synergistic therapy;

    机译：PDT;NMOFS;修改;癌症;协同疗法;

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