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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Immunoactive photosensitizers had photodynamic immunostimulatory and immunomodulatory effects on mammalian macrophages
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Immunoactive photosensitizers had photodynamic immunostimulatory and immunomodulatory effects on mammalian macrophages

机译：免疫光敏剂对哺乳动物巨噬细胞具有光动力免疫刺激和免疫调节作用

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摘要

Photodynamic compounds have great potential in biological applications. Their controlled and localized activation with specific wavelength of light provides opportunities to potentially evade the side effects of today's cancer therapies. Biologically compatible photosensitizers can be used in therapy against cancer, infections as well as inflammatory and immune disorders. In this study, we examined chlorophyll derivatives for antimicrobial, immunostimulatory and immunomodulatory activities. Under dark conditions, these chlorophyll derivatives had strong anti-microbial activities on gram positive S.aureus and gram negative E.coli. Photo activation of the chlorophyll derivatives did not alter their anti-microbial activities on gram negative or gram positive bacteria. In order to examine how these anti-microbial chlorophyll derivatives might effect immune reaction of macrophages, they were tested on mammalian macrophages. They had immunostimulatory activities on them in the dark conditions since they led to increased TNF and IL6 cytokine production even in the absence of stimulants lipopolysaccharide (LPS) and lipoteichoic acid (LTA). Photo-activation of the compounds led to decrease in pro-inflammatory cytokines, TNF and IL6, production by LPS or LTA activated macrophages. Therefore, these molecules can be used to regulate the immune response in the patients with bacterial infection while leading to death of bacteria. Light induced activation of the compounds could enable localized and controlled activation of their anti-inflammatory effects.
机译：光动力化合物在生物应用中具有很大的潜力。它们具有特定波长的光的控制和局​​部激活提供了可能避免当今癌症疗法的副作用的机会。生物学相容的光敏剂可用于治疗癌症，感染以及炎症和免疫障碍。在这项研究中，我们检查了抗微生物，免疫调节和免疫调节活动的叶绿素衍生物。在暗条件下，这些叶绿素衍生物在革兰氏阳性癌和革兰氏阴性的抗微生物活动中具有强烈的抗微生物活性。叶绿素衍生物的照片活化不会在革兰氏阴性或革兰氏阳性细菌上改变它们的抗微生物活性。为了检查这些抗微生物叶绿素衍生物如何影响巨噬细胞的免疫反应，它们在哺乳动物巨噬细胞上进行了测试。它们在黑暗条件下对它们具有免疫刺激活动，因为它们即使在没有兴奋剂脂多糖（LPS）和脂素酸（LTA）的情况下也导致TNF和IL6细胞因子产生增加。化合物的光活化导致促炎细胞因子，TNF和IL6降低，LPS或LTA活化巨噬细胞的产生。因此，这些分子可用于调节细菌感染患者的免疫应答，同时导致细菌死亡。光诱导化合物的活化可以使其局部化和控制活化的抗炎作用。

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