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Diagnostic accuracy of photodynamic diagnosis for upper urinary tract urothelial carcinoma: A systematic review and meta-analysis

机译:上尿道尿路上皮癌光动力诊断的诊断准确性:系统审查与荟萃分析

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Background: This study aimed to evaluate the effectiveness of photodynamic diagnosis (PDD) for upper urinary tract urothelial carcinoma (UTUC) by performing a meta-analysis.Method: Relevant articles were retrieved from the Cochrane Library, PubMed, and Embase databases. Studies evaluating the accuracy of PDD for the diagnosis of upper UTUC were included. The pooled sensitivity, specificity, and area under the curve (AUC) were calculated by STATA 16.0 at the per-lesion level.Results: Six studies with 289 lesions were included in this systematic review and meta-analysis. The pooled results showed that PDD can differentiate upper UTUC from benign lesions with a sensitivity of 0.96 (95 % confidence interval: 0.85 0.99) and a specificity of 0.86 (95 % confidence interval: [0.64-0.95]; AUC, 0.97). Compared with white-light ureterorenoscopy, PDD can significantly improve the additional detection rate of UTUC (RR 0.16, 95 % CI 0.07-0.34 P = 0.000).Conclusions: PDD is a valid technique that improves the diagnostic accuracy of UTUC compared with standard white-light ureterorenoscopy at the per-lesion level. PDD is a promising endoscopic technique for upper UTUC.
机译:背景:本研究旨在通过进行META分析来评估上尿道尿路上皮癌(UTUC)的光动力诊断(PDD)的有效性。方法:从Cochrane文库,PubMed和Embase数据库中检索相关物品。还包括评估PDD精度进行诊断上部UTUC的准确性。曲线(AUC)下的汇集敏感性,特异性和面积由STATA 16.0在每病变水平下计算。结果:在该系统审查和荟萃分析中,六项研究涉及289例病变。合并的结果表明,PDD可以将上部Utuc与良性病变区分开,灵敏度为0.96(95%置信区间:0.85 0.99)和0.86的特异性(95%置信区间:[0.64-0.95]; AUC,0.97)。与白光输尿管镜检查相比,PDD可以显着提高UTUC的额外检测率(RR 0.16,95%CI 0.07-0.34 P = 0.000)。CONCLUSIONS:PDD是一种有效的技术,可提高utuc与标准白色诊断准确性的有效技术 - 按病变水平的尿点镜检查。 PDD是对上部utuc的有希望的内窥镜技术。

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