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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Development and in vitro evaluation of buccal mucoadhesive films for photodynamic inactivation of Candida albicans
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Development and in vitro evaluation of buccal mucoadhesive films for photodynamic inactivation of Candida albicans

机译：对念珠菌灭活的颊粘膜粘附膜的开发和体外评价念珠菌灭活

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摘要

Candidiasis is one of the most common diseases that occur in the oral cavity, caused mainly by the species Candida albicans. Methylene blue (MB) has a potential for microbial photoinactivation and can cause the destruction of fungi when applied in Photodynamic Therapy (PDT). Mucoadhesive films are increasingly being studied as a platform for drug application due to their advantages when compared to other pharmaceutical forms. The aim of this work was to develop mucoadhesive buccal film containing poloxamer 407 (P407), alcohol polyvinyl (PVA) and polyvinylpyrrolidone (PVP) for the release of MB aiming the photoinactivation of Candida albicans in buccal infections. Different amounts of P407 were added to the binary polymeric blends composed PVA and PVP. Formulations were characterized as morphology, thickness, density, bending strength, mechanical properties, water vapor transmission, disintegration time, mucoadhesion, DSC, ATR-FTIR, in vitro drug release profile and photodynamic inactivation. The films displayed physicochemical characteristics dependent of polymeric composition, mucoadhesive properties, fast MB release and were effective in photo inactivate the local growth of Candida albicans isolates. The formulation containing the lowest PVA and P407 amounts displayed the best performance. Therefore, data obtained from the film system show its potentially useful role as a platform for buccal MB delivery in photoinactivation of C. albicans, showing its potential for in vivo evaluation.
机译：念珠菌病是口腔中最常见的疾病之一，主要由念珠菌念珠菌造成的。亚甲基蓝（MB）具有微生物光灭活的可能性，并且在光动力治疗（PDT）中施用时会导致真菌的破坏。与其他药物形式相比，粘膜粘土薄膜越来越多地研究了药物应用的平台。这项工作的目的是开发含有泊洛沙姆407（P407），醇聚乙烯（PVA）和聚乙烯吡咯烷酮（PVP）的粘膜粘附性颊膜，用于释放MB，其旨在在口腔感染中的念珠菌蛋白酶的光灭绝。将不同量的P407加入到组合的PVA和PVP的二元聚合物共混物中。制剂的特征在于形态，厚度，密度，弯曲强度，机械性能，水蒸气透射，崩解时间，粘膜粘附，DSC，ATR-FTIR，体外药物释放曲线和光动力灭活。薄膜显示出依赖聚合物组合物，粘膜粘附性，快速MB释放的物理化学特性，并且在光灭活的照片中有效，念珠菌蛋白酶分离物的局部生长。含有最低PVA和P407的配方呈现最佳性能。因此，从薄膜系统获得的数据显示其潜在有用的作用作为C.古木儿的PhotoCactivation中的颊部MB递送的平台，显示其在体内评价中的潜力。

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