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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Efficacy of aminolevulinic acid 20 % solution photodynamic therapy in the treatment of actinic keratoses on the upper extremities: A post hoc analysis of a phase 3, randomized, vehicle-controlled trial
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Efficacy of aminolevulinic acid 20 % solution photodynamic therapy in the treatment of actinic keratoses on the upper extremities: A post hoc analysis of a phase 3, randomized, vehicle-controlled trial

机译：氨基乙酸20％溶液光动力疗法在上肢上处理光学角膜的疗效：第3阶段，随机，车辆对照试验的后HOC分析

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摘要

Background: Photodynamic therapy with 5-aminolevulinic acid is indicated for targeted treatment of actinic keratoses on the face, scalp, and upper extremities. This was a post hoc analysis of a phase 3 randomized trial assessing the efficacy of aminolevulinic acid/photodynamic therapy for treatment of actinic keratoses on the upper extremities.Methods: Adults with 4-15 grade 1-2 actinic keratosis lesions on = 1 upper extremity were randomized (1:1) to receive aminolevulinic acid/photodynamic therapy or vehicle/photodynamic therapy applied to individual lesions followed by occlusion and blue light treatment. Assessments included the clearance rate of treated lesions vs baseline, cumulative disease area clearance, and complete clearance by lesion size.Results: There were 135 and 134 patients randomized to aminolevulinic acid/photodynamic therapy and vehicle/photodynamic therapy groups, respectively. At 12 weeks, clearance of treated lesions (80.6 % vs 45.5 %; P 0.0001) and the mean decrease in cumulative disease area (82.4 % vs 42.6 %; P 0.0001) was significantly higher for aminolevulinic acid/photodynamic therapy vs vehicle/photodynamic therapy, respectively. Rates of complete clearance and clearance by cutpoint (= 90 %, = 85 %, = 80 %, or = 75 % clearance) were numerically higher for aminolevulinic acid/photodynamic therapy. Clearance of lesions was higher for aminolevulinic acid/photodynamic therapy vs vehicle/photodynamic therapy regardless of baseline lesion size. Aminolevulinic acid/photodynamic therapy was well tolerated with adverse events consistent with those expected with photodynamic therapy.Conclusions: Aminolevulinic acid photodynamic therapy is effective and well tolerated for the treatment of actinic keratosis lesions of the extremities.
机译：背景：用5-氨基乙酰丙酸的光动力学治疗表明面部，头皮和上肢的靶向治疗活性角膜。这是对第3期随机试验的后HOC分析，评估氨基乙酰酸/光动力治疗治疗上肢的光化角质的疗效。方法：成年人4-15级1-2型光化角膜病变部> = 1次末端被随机（1：1）接受施用于各个病变的氨基硫酸/光动力治疗或载体/光动力学治疗，然后闭塞和蓝光处理。评估包括治疗病变的许可率与基线，累积疾病区域间隙，并通过病变规模完全清除。结果：分别有135和134名患者分别对氨基乙酰丙烯酸/光动力治疗和载体/光动力治疗组。 12周，治疗病变的清除（80.6％vs 45.5％; p <0.0001）和累积疾病面积的平均下降（82.4％与42.6％; p <0.0001）对于氨基乙酰乙烯酸/光动力治疗VS车辆显着提高，VS车辆/分别光动力学治疗。对于氨基乙酰丙烯酸/光动力治疗，切位点（> = 90％，> = 85％，> = 80％，> = 75％间隙）的完全间隙和清除率。对于氨基纤维酸/光动力治疗的血管/光动力疗法而言，病变的清除较高，无论基线病变大小如何。氨基纤维酸/光动力学治疗与具有光动力治疗的预期的那些不良事件良好耐受。结论：氨基纤维酸光动力治疗是有效的，耐受性耐受性，用于治疗末端的光碱角化病变。

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  • 来源
    《Photodiagnosis and Photodynamic Therapy》 |2020年第12期|102013.1-102013.5|共5页
  • 作者

    Berman Brian; Bhatia Neal; Piacquadio Daniel; Houlihan Anna; Davidson David; Siegel Daniel;

  • 作者单位

    Ctr Clin & Cosmet Res 2925 Aventura Blvd Suite 205 Aventura FL 33180 USA|Univ Miami Dr Phillip Frost Dept Dermatol & Cutaneous Surg Miller Sch Med 1295 NW 14th St Suite K-M Miami FL 33136 USA;

    Therapeut Clin Res 9025 Balboa Ave Suite 105 San Diego CA 92123 USA;

    Therapeutics Inc 9025 Balboa Ave Suite 100 San Diego CA 92123 USA;

    DUSA Pharmaceut Inc 25 Upton Dr Wilmington MA 01887 USA;

    Sun Pharmaceut Ind Inc 2 Independence Way Princeton NJ 08540 USA;

    State Univ New York Downstate Hlth Sci Univ Dept Dermatol 450 Clarkson Ave Brooklyn NY 11203 USA|Vet Affairs New York Harbor Healthcare Syst Dermatol Serv 800 Poly Pl Brooklyn NY 11209 USA;

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  • 正文语种 eng
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  • 关键词

    Actinic keratosis; Photodynamic therapy; 5-Aminolevulinic acid; Extremities;

    机译：光学角化症;光动力疗法;5-氨基乙酰丙酸;四肢;

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