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首页> 外文期刊>Photodiagnosis and Photodynamic Therapy >Sulfonated hydroxyaluminum phthalocyanine-biogenic Au/Ag alloy nanoparticles mixtures for effective photo-eradication of Candida albicans
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Sulfonated hydroxyaluminum phthalocyanine-biogenic Au/Ag alloy nanoparticles mixtures for effective photo-eradication of Candida albicans

机译：磺化羟铝磷酸酞菁 - 生物苷Au / Ag合金纳米粒子混合物用于有效的念珠菌念珠菌

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摘要

In response to the increasingly widespread resistance of fungi to traditional treatment, we have reported successful photodynamic inactivation of Candida albicans planktonic cells using di-(AlPcS2) and trisulfonated (AlPcS3) hydroxyaluminum phthalocyanines in combination with Au/Ag alloy nanoparticles synthesized by the cell-free filtrate of Trichoderma koningii. These nanostructures with Au:Ag molar ratios 2:1, 1:1 and 1:2 have individual plasmonic band at 513 515 nm, 505 509 nm and 486 489 nm, respectively. XPS analysis of the ratio of gold to silver on the surface of these alloys indicated that Au and Ag formed a bimetallic system, wherein Au was coated with Ag. The XRD pattern revealed the angles at 38.2, 44.5, 64.9 and 78.0 degrees. TEM analysis indicated that the average diameter of the synthesized alloys was 9 +/- 3 nm, 8 +/- 3 nm and 16 +/- 3 nm for structures with Au:Ag molar ratios 1:1, 1:2 and 2:1, respectively. The FTIR band absorption, SEM-EDS analysis and basic elemental composition obtained by XPS confirmed that these nanostructures are stabilized by protein (s).Diode laser with the peak-power wavelength lambda = 650 nm (output power of 40 mW; power density of 105 mW cm(-2)) was used as a light source. The mixture of AlPcS2+Au/Ag-NPs (Au:Ag = 2:1) can be considered as an effective photosensitizer, because eradication of C. albicans, as required by the American Society of Microbiology (99.9 %), was achieved at a low dose of light of 31.5 J cm(-2). It was postulated that this low dose of light applied to the photo-induced fungicidal effect may be painless for potential patients.
机译：为了应对真菌对传统治疗的越来越广泛的抗性，我们已经报道了使用DI-（ALPCS2）和三磺酰化（ALPCS3）羟基铝酞菁与细胞合成的Au / Ag合金纳米颗粒组合的念珠菌（Alpcs3）羟基铝磷砜蛋白酶成功的光动力灭活Trichoderma Koningii的免费滤液。这些纳米结构与Au：Ag摩尔比例2：1,1：1和1：2分别在513 515nm，505 509nm和486 489nm处具有单个等离子体带。 XPS分析金对银在这些合金表面上的比例表明Au和Ag形成了双金属系统，其中Au被Ag涂覆。 XRD模式显示38.2,44.5,64.9和78.0度的角度。 TEM分析表明，合成合金的平均直径为9 +/- 3nm，8 +/- 3nm和16 +/- 3nm，用于Au：Ag摩尔比例1：1,1：2和2：分别为1。通过XPS获得的FTIR带吸收，SEM-EDS分析和基本元素组合物证实，这些纳米结构通过蛋白质，峰值激光稳定，峰值功率波长Lambda = 650nm（输出功率为40 mW;功率密度使用105mm cm（-2））作为光源。 ALPCS2 + AU / AG-NPS（AU：AG = 2：1）的混合物可被认为是一种有效的光敏剂，因为根据美国微生物学会（99.9％）的要求，消除了C. albicans（99.9％）。低剂量的31.5J厘米（-2）。假设施加到光诱导的杀真菌效果的这种低剂量的光可能是潜在患者的痛苦。

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