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Modeling magnetic nanoparticle dipole-dipole interactions inside living cells

机译：模拟活细胞内部的磁性纳米粒子偶极-偶极相互作用

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摘要

Biomedical applications based on superparamagnetic nanoparticles injected in vivo may be affected by the cellular uptake of these nanoparticles. Living cells indeed capture and internalize nanoparticles, concentrating them into intracellular vesicles called lysosomes. As a consequence, nanoparticles interact magnetically with each other, modifying their magnetic properties. The effects of cellular uptake can be observed on the temperature dependence of zero-field cooled (ZFC) magnetization, which is known to be sensitive to magnetic interactions. In this paper, a theoretical model is proposed to account for weak magnetic interactions between nanoparticles aggregated into spherical compartments. This model suggests a new interpretation of the maximum of the ZFC curve, uncorrelated with the nanoparticle relaxation time but with the extent of interaction effects. It focuses on the local field felt by each nanoparticle, which is the sum of the applied magnetic field and the field created by all the other nanoparticles. For the considered organization of nanoparticles, only the field created by touching neighbors has to be taken into account, setting up the local nanoparticle volume fraction as the unique parameter of the model. This parameter relates the global magnetization measurements to the local distribution of nanoparticles in cells and tissues or in other complex media with aggregated organization.
机译：基于体内注射的超顺磁性纳米粒子的生物医学应用可能会受到这些纳米粒子的细胞摄取的影响。活细胞确实捕获并内化了纳米颗粒，将它们浓缩到称为溶酶体的细胞内囊泡中。结果，纳米颗粒彼此磁性相互作用，从而改变了它们的磁性。可以观察到细胞吸收对零场冷（ZFC）磁化的温度依赖性的影响，该磁场对磁相互作用很敏感。在本文中，提出了一个理论模型来解决聚集到球形隔室中的纳米颗粒之间的弱磁性相互作用。该模型提出了对ZFC曲线最大值的新解释，该解释与纳米粒子弛豫时间无关，但与相互作用效应有关。它着重于每个纳米粒子感受到的局部场，该场是所施加磁场与所有其他纳米粒子产生的场的总和。对于考虑的纳米粒子组织，只需考虑通过触摸邻居创建的场，将局部纳米粒子的体积分数设置为模型的唯一参数。该参数将整体磁化强度的测量值与纳米粒子在细胞和组织或其他具有聚集组织的复杂介质中的局部分布相关。

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  • 来源
    《Physical review》 |2011年第7ptab期|p.075480.1-075480.11|共11页
  • 作者

    Michael Levy; Florence Gazeau; Jean-Claude Bacri; Claire Wilhelm; Martin Devaud;

  • 作者单位

    Laboratoire Matiere et Systemes Complexes (MSC), UMR CNRS 7057, Universite Paris-Diderot, Batiment Condorcet-Case 7056,F-75205 Paris Cedex 13, France;

    Laboratoire Matiere et Systemes Complexes (MSC), UMR CNRS 7057, Universite Paris-Diderot, Batiment Condorcet-Case 7056,F-75205 Paris Cedex 13, France;

    Laboratoire Matiere et Systemes Complexes (MSC), UMR CNRS 7057, Universite Paris-Diderot, Batiment Condorcet-Case 7056,F-75205 Paris Cedex 13, France;

    Laboratoire Matiere et Systemes Complexes (MSC), UMR CNRS 7057, Universite Paris-Diderot, Batiment Condorcet-Case 7056,F-75205 Paris Cedex 13, France;

    Laboratoire Matiere et Systemes Complexes (MSC), UMR CNRS 7057, Universite Paris-Diderot, Batiment Condorcet-Case 7056,F-75205 Paris Cedex 13, France;

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