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首页> 外文期刊>Phytochemistry Reviews >A bitter plant with a sweet future? A comprehensive review of an oriental medicinal plant: Andrographis paniculata
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A bitter plant with a sweet future? A comprehensive review of an oriental medicinal plant: Andrographis paniculata

机译：苦涩的植物，前程似锦？东方药用植物：穿心莲的全面综述

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摘要

Andrographis paniculata (Burm.f) Nees is one of the most popular and important medicinal plant of the Orient, and South East Asia. It finds mention in various forms in Indian, Chinese, Malay, Thai, Unani, and Japanese systems of medicine. The plant exhibits anti-cancer, anti-inflammatory, anti-diabetic, anti-hypertensive, anti-venom, cholestatic, hepatoprotective, anti-thrombotic, anti-retroviral, anti-microbial, anti-pyretic, anti-malarial, anti-oxidant, immunomodulatory, and cardioprotective effects. The major active principles contributing to biological activity are diterpene lactones, but flavonoids, xanthones and caffeic acid derivatives also contribute to anti-oxidant, anti-proliferative, anti-atherosclerotic, and anti-malarial effects. As a result of its wide spectrum of pharmacological activity, almost impeccable safety profile, being a widely cultivated medicinal plant, we have collected and compiled various facets of this plant. Extensive datamining of the phytochemistry and pharmacology of Andrographis paniculata revealed more than 50 diterpene lactones, 30 flavonoids, 8 quinic acid derivatives, and 4 xanthones. This review contains information on around 80 isolated compounds, out of which more than half of the compounds have no reported pharmacological activity. Though there are some good reviews available on Andrographis paniculata, the authors of the earlier reviews focused on one or two aspects of the plant and none have attempted to integrate the available information on this plant. This provided us the much needed impetus, warranting a full-fledged and complete review on Andrographis paniculata, one of the most popular and important Oriental medicinal plant.
机译：穿心莲（Burm.f）Nees是东方和东南亚地区最受欢迎和最重要的药用植物之一。它在印度，中国，马来语，泰语，乌纳尼和日本的医学体系中以各种形式被提及。该植物表现出抗癌，抗炎，抗糖尿病，抗高血压，抗蛇毒，胆汁淤积，保肝，抗血栓形成，抗逆转录病毒，抗微生物，抗退热，抗疟疾，抗氧化，免疫调节和心脏保护作用。有助于生物活性的主要活性成分是二萜内酯，但类黄酮，黄嘌呤和咖啡酸衍生物也有助于抗氧化，抗增殖，抗动脉粥样硬化和抗疟疾作用。由于其广泛的药理活性，几乎无可挑剔的安全性，作为一种广泛种植的药用植物，我们收集并整理了该植物的各个方面。穿心莲的植物化学和药理作用的大量数据挖掘揭示了50多种二萜内酯，30种黄酮类，8种奎尼酸衍生物和4种氧杂蒽酮。这篇综述包含大约80种分离出的化合物的信息，其中超过一半的化合物没有报道的药理活性。尽管穿心莲有一些不错的评论，但早期评论的作者专注于植物的一个或两个方面，没有人试图整合有关该植物的可用信息。这为我们提供了急需的动力，从而保证了对穿心莲（一种最受欢迎​​和最重要的东方药用植物之一）进行全面完整的评估。

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