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Steroid hormones in multiple tissues of East Greenland polar bears (Ursus maritimus)

机译：东格陵兰北极熊（Ursus maritimus）多个组织中的类固醇激素

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摘要

The polar bear (Ursus maritimus) is threatened by climate changes and also from persistent organic pollutants affecting polar bear endocrinology governing growth and reproduction. To provide further insight into basic polar bear endocrinology, we determined the levels of steroids in multiple tissues and plasma from East Greenland polar bears. Tissue samples from 10 polar bears, 5 males (2 adults, 3 juveniles) and 5 females (all juveniles) were obtained from the Inuit hunt in Scoresby Sound during springtime. Eleven steroids: pregnenolone, 17-hydroxypregnenolone, progesterone, 17-hydroxyprogesterone, dehydroepiandrosterone, androstenedione, testosterone, dihydrotestosterone, estrone, 17 alpha-estradiol and 17 beta-estradiol were determined in brain, adrenal cortex, testis, testicular vein, plasma, and ovary using GC-MS/MS. In brain tissue, the neuroactive progestagen pregnenolone (11.9 +/- 4.4 ng/g ww) and dehydroepiandrosterone (2.26 +/- 0.43 ng/g ww) were found in high concentrations. Very high levels of testosterone and androstenedione were observed in testes (> 100 ng/g ww) and plasma from testicular vein (testosterone: 108 +/- 41 ng/ml; androstenedione: 35.2 +/- 11.1 ng/ml). Additionally, a strong correlation was found between the levels of steroids in testes and testicular vein plasma. Progestagens were found in very high levels in ovaries from juvenile females (> 100 ng/g ww). Finally, our study indicates that polar bears synthesize androstenedione via the a dagger-4 pathway. The present study adds new insight to our knowledge on polar bear endocrinology, which may be used in future studies on polar bear ecology and studies on some of the threats from pollution and climate changes that these animals are facing.
机译：北极熊（Ursus maritimus）受到气候变化的威胁，也受到影响北极熊内分泌学（控制生长和繁殖）的持久性有机污染物的威胁。为了进一步了解基本的北极熊内分泌学，我们确定了东格陵兰北极熊的多个组织和血浆中类固醇的水平。在春季从Scoresby Sound的因纽特人狩猎中获得了10只北极熊，5只雄性（2名成年人，3个少年）和5只雌性（所有少年）的组织样本。在大脑，肾上腺皮质，睾丸，睾丸静脉，血浆和血浆中测定了11种类固醇：孕烯醇酮，17-羟基孕烯醇酮，孕酮，17-羟基孕酮，脱氢表雄酮，雄烯二酮，睾丸激素，二氢睾丸酮，雌酮，17α-雌二醇和17-β-雌二醇。卵巢使用GC-MS / MS。在脑组织中，发现高浓度的神经活性孕激素孕烯醇酮（11.9 +/- 4.4 ng / g重量）和脱氢表雄酮（2.26 +/- 0.43 ng / g重量）。在睾丸（> 100 ng / g ww）和睾丸静脉血浆中观察到非常高水平的睾丸激素和雄烯二酮（睾丸激素：108 +/- 41 ng / ml;雄烯二酮：35.2 +/- 11.1 ng / ml）。此外，在睾丸和睾丸静脉血浆中的类固醇水平之间发现强烈的相关性。未成年女性卵巢中的孕激素含量很高（> 100 ng / g ww）。最后，我们的研究表明，北极熊通过dagger-4途径合成雄烯二酮。本研究为我们对北极熊的内分泌学知识增添了新的见解，可用于未来的北极熊生态学研究以及这些动物面临的污染和气候变化带来的某些威胁的研究。

著录项

  • 来源
    《Polar biology》 |2017年第1期|37-49|共13页
  • 作者

    Styrishave Bjarne; Pedersen Kathrine Eggers; Clarke Olivier; Hansen Martin; Bjorklund Erland; Sonne Christian; Dietz Rune;

  • 作者单位

    Univ Copenhagen, Toxicol Lab, Dept Pharm, Fac Hlth & Med Sci, Univ Pk 2, DK-2100 Copenhagen O, Denmark;

    Univ Copenhagen, Toxicol Lab, Dept Pharm, Fac Hlth & Med Sci, Univ Pk 2, DK-2100 Copenhagen O, Denmark;

    Univ Copenhagen, Toxicol Lab, Dept Pharm, Fac Hlth & Med Sci, Univ Pk 2, DK-2100 Copenhagen O, Denmark;

    Univ Copenhagen, Toxicol Lab, Dept Pharm, Fac Hlth & Med Sci, Univ Pk 2, DK-2100 Copenhagen O, Denmark;

    Univ Copenhagen, Toxicol Lab, Dept Pharm, Fac Hlth & Med Sci, Univ Pk 2, DK-2100 Copenhagen O, Denmark|Kristianstad Univ, Sch Educ & Environm, Div Nat Sci, S-29188 Kristianstad, Sweden;

    Aarhus Univ, Fac Sci & Technol, Dept Biosci, ARC, Frederiksborgvej 399,POB 358, DK-4000 Roskilde, Denmark;

    Aarhus Univ, Fac Sci & Technol, Dept Biosci, ARC, Frederiksborgvej 399,POB 358, DK-4000 Roskilde, Denmark;

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  • 正文语种 eng
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  • 关键词

    Androgens; Estrogens; Progestagens; Sex steroids; Steroidogenesis; Testis; Testicular vein blood; Ovary; Brain; Neurosteroids;

    机译：雄激素;雌激素;孕激素;性类固醇;类固醇生成;睾丸;睾丸静脉血;卵巢;脑;神经固醇;

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