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首页> 外文期刊>Polish Journal of Environmental Studies >Investigating the Ameliorative Potential of the Aloe barbadensis Aqueous Fraction on Oxidative Stress Markers and Biochemical Parameters in Cadmium-Intoxicated Rabbits
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Investigating the Ameliorative Potential of the Aloe barbadensis Aqueous Fraction on Oxidative Stress Markers and Biochemical Parameters in Cadmium-Intoxicated Rabbits

机译：研究巴氏芦荟水溶液组分对镉中毒家兔氧化应激指标和生化指标的改善潜力

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This study was conducted to evaluate the possible protective effects of the flavonoid-rich fraction of Aloe barbadensis leaf skin on cadmium (Cd)-induced toxicity in male albino rabbits. Cadmium is a notable environmental pollutant due to its wider range of toxic manifestations. The aqueous fraction of aloe extract (AAF) showed higher phenolics, flavonoids, and antioxidant capacity among other fractions, suggesting its rationale use in this study. Twenty-four rabbits were randomly divided into four groups, including the control group (receiving only vehicle), the Cd group (receiving Cd, 5.1 mg/kg/day), the AAF groups (receiving AAF, 200 mg/Kg/day), and the Cd+AAF group (receiving the same concentrations as the Cd and AAF groups). Oral treatment over a period of 40 days significantly increased (p<0.05) biochemical marker enzymes, including transaminases (AST, ALT), alkaline phosphatase, gamma-glutamyl transferase, creatinine, and urea, while total bilirubin (Tb) and albumin were decreased on days 10, 20, 30, and 40 in the Cd group as compared to control. A significant decrease (p<0.05) in enzyme levels and increases in Tb and albumin for Cd+AAF were observed as compared to Cd-treated rabbits. Contents of superoxide dismutase, catalase, and vitamins C and E in liver and kidney tissues were significantly increased (p<0.05), while cadmium content was significantly decreased (p<0.05) for Cd+AAF rabbits as compared to Cd-intoxicated rabbits. Values of all the parameters in only the AAF group were near to control. The histopathological studies for liver and kidney have also supported the Cd+AAF group markedly reducing the toxicity of Cd in both tissues to near normal. Thus, the results suggest that the flavonoid-rich fraction of AAF may act as a natural protective agent against Cd toxicity via suppressing oxidative stress due to higher antioxidant activity.
机译：进行这项研究以评估芦荟叶皮肤富含类黄酮的成分对镉（Cd）诱导的雄性白化兔毒性的可能的保护作用。镉由于其广泛的毒性表现而成为显着的环境污染物。芦荟提取物（AAF）的水相馏分在其他馏分中显示出较高的酚类，类黄酮和抗氧化能力，这表明其在本研究中的用途。 24只兔随机分为四组，分别为对照组（仅接受赋形剂），Cd组（接受Cd，5.1 mg / kg /天），AAF组（接受AAF，200 mg / Kg /天）。 ，以及Cd + AAF组（接受与Cd和AAF组相同的浓度）。 40天的口服治疗显着增加（p <0.05）生化标记酶，包括转氨酶（AST，ALT），碱性磷酸酶，γ-谷氨酰转移酶，肌酐和尿素，而总胆红素（Tb）和白蛋白则降低Cd组在第10、20、30和40天与对照组相比。与Cd处理的兔子相比，Cd + AAF的酶水平显着降低（p <0.05），Tb和白蛋白升高。与中毒镉相比，Cd + AAF兔肝脏和肾脏组织中超氧化物歧化酶，过氧化氢酶以及维生素C和E的含量显着增加（p <0.05），而镉含量显着降低（p <0.05）。仅AAF组中所有参数的值都接近于控制。肝脏和肾脏的组织病理学研究也支持Cd + AAF组将Cd在两个组织中的毒性显着降低至接近正常水平。因此，结果表明，AAF的富含类黄酮的部分可通过抑制由于较高抗氧化剂活性引起的氧化应激而充当抗Cd毒性的天然保护剂。

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