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In vitro and in vivo degradation of an injectable bone repair composite

机译：可注射骨修复复合物的体外和体内降解

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摘要

In vitro and in vivo degradation behaviors of an injectable bone regeneration composite (IBRC) which comprised of nano-hydroxyapatite/collagen (nHAC) particles in alginate hydrogel carrier were investigated. In vitro degradation quantitative testing indicated that the alginate had a faster degradation rate in simulated body fluid (SBF) than in deionized water at 37 ℃. Similarly, IBRC also had a higher degradation rate in SBF than in deionized water at 37 ℃, which was evaluated by alginate molecular weight measurement, mechanical properties test and degradation kinetics evaluation. But molecular weight of alginate degraded slower in IBRC than that in aqueous solution. In vitro results showed that degradation medium SBF had influence on degradation of alginate molecules. In the in vivo degradation study, surprisingly, there was no obvious decreasing of molecular weight of alginate from 0 to 8 weeks. IBRC degraded mostly after 24 weeks implantation and was replaced by connective tissue. No fibrous capsule and acute inflammatory reaction were found during the observed 24 weeks after IBRC implantation. There is only a mild short-term inflammatory response in rat dorsum muscle. These results indicated that IBRC had a controllable degradability and biocompatibility. Therefore, IBRC may be a promising degradable material for bone repair and bone tissue engineering.
机译：研究了藻酸盐水凝胶载体中包含纳米羟基磷灰石/胶原蛋白（nHAC）颗粒的可注射骨再生复合材料（IBRC）的体外和体内降解行为。体外降解定量测试表明，在37℃下，藻酸盐在模拟体液（SBF）中的降解速度要快于去离子水中的降解速度。同样，IBRC在37℃下的SBF降解速率也高于去离子水中，这是通过藻酸盐分子量测量，力学性能测试和降解动力学评估来评估的。但是在IBRC中，藻酸盐的分子量降解比在水溶液中降解的慢。体外结果表明，降解培养基SBF对藻酸盐分子的降解有影响。令人惊讶地，在体内降解研究中，藻酸盐的分子量从0到8周没有明显降低。 IBRC大部分在植入后24周降解，并被结缔组织代替。 IBRC植入24周后未观察到纤维囊和急性炎症反应。在大鼠背肌中仅有轻度的短期炎症反应。这些结果表明IBRC具有可控的降解性和生物相容性。因此，IBRC可能是用于骨修复和骨组织工程的有前途的可降解材料。

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  • 来源
    《Polymer Degradation and Stability》 |2010年第9期|p.1736-1742|共7页
  • 作者

    Rongwei Tan; rnQingling Feng; rnZhengding She; rnMingbo Wang; rnHe Jin; rnJinyu Li; rnXing Yu;

  • 作者单位

    State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China;

    rnState Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China;

    rnCenter for Advanced Materials and Biotechnology, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China;

    rnState Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China;

    rnDepartment of Orthopaedics, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China;

    rnDepartment of Orthopaedics, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China;

    rnDepartment of Orthopaedics, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China;

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  • 正文语种 eng
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  • 关键词

    in vitro; in vivo; degradation; injectable; bone repair;

    机译：体外;体内;降解;注射剂骨修复;

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