• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the Institution of Mechanical Engineers. Part K, Journal of Multi-body Dynamics >Three-dimensional modeling and simulation of the AFM-based manipulation of spherical biological microanoparticles with the consideration of contact mechanics theories
【24h】

Three-dimensional modeling and simulation of the AFM-based manipulation of spherical biological microanoparticles with the consideration of contact mechanics theories

机译：考虑接触力学理论的基于AFM的球形生物微粒/纳米粒子操纵的三维建模和仿真

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

By using an atomic force microscope as an ideal instrument for the manipulation of biological particles, the user deprives herself of the direct observation of the manipulation process in real time. In order to understand this process and to remove this limitation, an auxiliary method should be adopted which itself is not hampered by such a constraint. One of the approaches that has become of interest in this regard is the atomic force microscope based modeling and simulation of the manipulation process. Up to now, two-dimensional simulations have been performed using this technique; and as for three-dimensional modeling, only non-biological particles with cylindrical geometries have been investigated without the consideration of contact mechanics. For the first time, the present research has focused on the three-dimensional modeling and simulation of spherical biological particles in air medium while considering the mechanics of contact. Based on the simulation results, the manipulation force and indentation depth values that are produced in the contacts made during the manipulation process depend on the properties of the biological microanoparticles involved; and in comparison with the two-dimensional case, increased values of manipulation force, contact radius and indentation depth have been observed in the three-dimensional models.
机译：通过使用原子力显微镜作为操作生物颗粒的理想工具，用户无法直接实时观察操作过程。为了理解该过程并消除该限制，应采用一种辅助方法，该辅助方法本身不受此约束的影响。在这方面引起关注的方法之一是基于原子力显微镜的操纵过程建模和仿真。到目前为止，已经使用这种技术进行了二维模拟。对于三维建模，仅研究了具有圆柱几何形状的非生物粒子，而没有考虑接触力学。本研究首次将空气介质中球形生物颗粒的三维建模与仿真同时考虑了接触力学。根据模拟结果，在操纵过程中所产生的接触中产生的操纵力和压入深度值取决于所涉及的生物微粒/纳米粒子的特性。与二维情况相比，在三维模型中观察到了操纵力，接触半径和压痕深度的增加值。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号