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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Modulation of protein tyrosine phosphorylation in rat insular cortex after conditioned taste aversion training.
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Modulation of protein tyrosine phosphorylation in rat insular cortex after conditioned taste aversion training.

机译：条件化厌恶训练后大鼠岛状皮质中蛋白质酪氨酸磷酸化的调节。

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摘要

Protein tyrosine phosphorylation is a major signal transduction pathway involved in cellular metabolism, growth, and differentiation. Recent data indicate that tyrosine phosphorylation also plays a role in neuronal plasticity. We are using conditioned taste aversion, a fast and robust associative learning paradigm subserved among other brain areas by the insular cortex, to investigate molecular correlates of learning and memory in the rat cortex. In conditioned taste aversion, rats learn to associate a novel taste (e.g., saccharin) with delayed poisoning (e.g., by LiCl injection). Here we report that after conditioned taste aversion training, there is a rapid and marked increase in tyrosine phosphorylation of a set of proteins in the insular cortex but not in other brain areas. A major protein so modulated, of 180 kDa, is abundant in a membrane fraction and remains modulated for more than an hour after training. Exposure of the rats to the novel taste alone results in only a small modulation of the aforementioned proteins whereas administration of the malaise-inducing agent per se has no effect. To the best of our knowledge, this is the first demonstration of modulation of protein tyrosine phosphorylation in the brain after a behavioral experience.
机译：蛋白质酪氨酸磷酸化是参与细胞代谢，生长和分化的主要信号转导途径。最近的数据表明酪氨酸磷酸化在神经元可塑性中也起作用。我们使用条件味觉厌恶（一种由岛状皮层在其他大脑区域中服务的快速而强大的联想学习范例）来研究大鼠皮层学习与记忆的分子相关性。在条件性味觉厌恶中，大鼠学会将新的味觉（例如糖精）与延迟中毒（例如通过LiCl注射）联系起来。在这里，我们报告说，经过条件厌恶训练后，岛叶皮层中一组蛋白质的酪氨酸磷酸化迅速而显着增加，而在其他大脑区域则没有。如此调节的主要蛋白质为180 kDa，在膜级分中含量丰富，并且在训练后保持调节超过一个小时。仅使大鼠暴露于新的味道会导致上述蛋白质的少量调节，而施用不适感诱导剂本身没有作用。就我们所知，这是行为行为后大脑中蛋白质酪氨酸磷酸化调节的首次证明。

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