Purification and identification of pituitary cytotropic factor.

Porter JC; Ijames CF; Wang TC; Markey SP

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Purification and identification of pituitary cytotropic factor.

机译：垂体细胞因子的纯化和鉴定。

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摘要

It has been shown that the pituitary contains a cytotropic factor (CTF) that stimulates the secretion of catecholamines by dopaminergic neurons of the hypothalamus. In the present study, CTF was purified from rat pituitaries and found by means of mass spectrometric analysis to be adenosine. This finding was corroborated by the observations that CTF behaves identically to adenosine when subjected to liquid chromatography, is inactivated and converted to inosine by adenosine deaminase, and is qualitatively and quantitatively indistinguishable from adenosine in its biological activity. It is concluded that pituitary adenosine is a trophic factor for hypothalamic dopaminergic neurons.

机译：已经表明，垂体含有促细胞因子（CTF），该因子刺激下丘脑的多巴胺能神经元分泌儿茶酚胺。在本研究中，从大鼠垂体中纯化了CTF，并通过质谱分析发现其为腺苷。观察发现证实了这一发现，即CTF在进行液相色谱分析时的行为与腺苷相同，通过腺苷脱氨酶被灭活并转化为肌苷，并且在定性和数量上与腺苷的生物学活性没有区别。结论是垂体腺苷是下丘脑多巴胺能神经元的营养因子。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第12期|P.5351-5355|共5页
作者
Porter JC; Ijames CF; Wang TC; Markey SP;
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作者单位

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235-9032, USA.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Adenosine; Pituitary Gland; Catecholamines; 腺苷; 垂体;

机译：Adenosine;Pituitary Gland;Catecholamines;腺苷;垂体;

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Purification and identification of pituitary cytotropic factor.

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