...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.
【24h】

Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe.

机译：Shk1是酿酒酵母Ste20和哺乳动物p65PAK蛋白激酶的同源物，是裂殖酵母粟酒裂殖酵母中Ras / Cdc42信号传导模块的组成部分。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We describe a protein kinase, Shk1, from the fission yeast Schizosaccharomyces pombe, which is structurally related to the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases. We provide genetic evidence for physical and functional interaction between Shk1 and the Cdc42 GTP-binding protein required for normal cell morphology and mating in S. pombe. We further show that expression of the STE20 gene complements the shk1 null mutation and that Shk1 is capable of signaling to the pheromone-responsive mitogen-activated protein kinase cascade in S. cerevisiae. Our results lead us to propose that signaling modules composed of small GTP-binding proteins and protein kinases related to Shk1, Ste20, and p65PAK, are highly conserved in evolution and participate in both cytoskeletal functions and mitogen-activated protein kinase signaling pathways.
机译：我们描述了裂变酵母裂殖酵母裂殖酵母的一种蛋白激酶Shk1，其结构上与酿酒酵母Ste20和哺乳动物p65PAK蛋白激酶有关。我们提供Shk1与正常细胞形态和S. pombe交配所需的Cdc42 GTP结合蛋白之间的物理和功能相互作用的遗传证据。我们进一步表明，STE20基因的表达与shk1空突变互补，并且Shk1能够信号传递至酿酒酵母中的信息素反应性促分裂原活化蛋白激酶级联反应。我们的结果使我们提出，由小GTP结合蛋白和与Shk1，Ste20和p65PAK相关的蛋白激酶组成的信号传导模块在进化中高度保守，并参与细胞骨架功能和丝裂原激活的蛋白激酶信号传导途径。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号