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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells.
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Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells.

机译：上皮内γδT细胞对肠道上皮的稳态调节。

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摘要

Although T cells bearing gamma delta T-cell receptors have long been known to be present in the epithelial lining of many organs, their specificity and function remain elusive. In the present study, we examined the intestinal epithelia of T-cell-receptor mutant mice, which were deficient in either gamma delta T cells or alpha beta T cells, and of normal littermates. The absence of gamma delta T cells was associated with a reduction in epithelial cell turnover and a downregulation of the expression of major histocompatibility complex class II molecules. No such effects were observed in alpha beta T-cell-deficient mice. These findings indicate that intraepithelial gamma delta T cells regulate the generation and differentiation of intestinal epithelial cells.
机译：尽管长期以来已知带有γ-δT细胞受体的T细胞存在于许多器官的上皮内膜中，但是它们的特异性和功能仍然难以捉摸。在本研究中，我们检查了T细胞受体突变小鼠的肠道上皮，这些小鼠的γδT细胞或αβT细胞以及正常同窝仔鼠均缺乏。伽玛三角洲T细胞的缺乏与上皮细胞周转的减少和主要组织相容性复杂II类分子的表达下调有关。在alpha beta T细胞缺陷小鼠中未观察到此类影响。这些发现表明上皮内γδT细胞调节肠上皮细胞的产生和分化。

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