...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >On the mechanism of skin wound 'contraction': a granulation tissue 'knockout' with a normal phenotype.
【24h】

On the mechanism of skin wound 'contraction': a granulation tissue 'knockout' with a normal phenotype.

机译：关于皮肤伤口“收缩”的机制：具有正常表型的肉芽组织“敲除”。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This report explores the mechanism of spontaneous closure of full-thickness skin wounds. The domestic pig, often used as a human analogue for skin wound repair studies, closes these wounds with kinetics similar to those in the guinea pig (mobile skin), even though the porcine dermis on the back is thick and nearly immobile. In the domestic pig, as in the guinea pig, daily full-thickness excisions of the central granulation tissue up to but not including the wound edges in both back and flank wounds do not alter the rate or completeness of wound closure or the final pattern of the scar. A purse-string mechanism of closure was precluded by showing that surgical interruption of wound edge continuity does not alter closure kinetics or wound shape. We conclude that "tightness" of skin is not a key factor nor is the central granulation tissue required for normal wound closure. These data imply that in vitro models such as contraction of isolated granulation tissue or of the cell-populated collagen lattice may not be relevant for understanding the cell biology of in vivo wound closure. Implications for the mechanism for wound closure are discussed.
机译：该报告探讨了自发闭合全层皮肤伤口的机制。经常被用作人类类似物进行皮肤伤口修复研究的家养猪用类似于豚鼠（活动皮肤）的动力学闭合这些伤口，即使背部的猪真皮厚且几乎不能移动。与豚鼠一样，在家养猪中，每日但不包括背部和后侧伤口的伤口边缘在内的中央肉芽组织的全层切除不会改变伤口闭合的速率或完整性或最终的结局。疤痕。通过显示伤口边缘连续性的外科手术中断不会改变闭合动力学或伤口形状，排除了闭合的字符串机制。我们得出结论，皮肤的“紧实度”不是关键因素，正常伤口闭合所需的中央肉芽组织也不是关键因素。这些数据暗示体外模型，例如分离的肉芽组织的收缩或细胞填充的胶原蛋白晶格的收缩，可能与理解体内伤口闭合的细胞生物学无关。讨论了伤口闭合机制的含义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号