Exponential increases of RNA virus fitness during large population transmissions.

Novella IS; Duarte EA; Elena SF; Moya A; Domingo E; Holland JJ

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Exponential increases of RNA virus fitness during large population transmissions.

机译：大量传播期间RNA病毒适应度呈指数增长。

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摘要

The great adaptability shown by RNA viruses is a consequence of their high mutation rates. Here we investigate the kinetics of virus fitness gains during repeated transfers of large virus populations in cell culture. Results always show that fitness increases exponentially. Low fitness clones exhibit regular increases observed as biphasic periods of exponential evolutionary improvement, while neutral clones show monophasic kinetics. These results are significant for RNA virus epidemiology, optimal handling of attenuated live virus vaccines, and routine laboratory procedures.

机译：RNA病毒显示出高适应性是其高突变率的结果。在这里，我们研究了在细胞培养中大量病毒种群的反复转移过程中病毒适应性增加的动力学。结果始终表明，适应度呈指数增长。低适应度克隆表现出规律的增长，观察到双相指数进化改善，而中性克隆表现出单相动力学。这些结果对于RNA病毒流行病学，减毒活病毒疫苗的最佳处理以及常规实验室程序具有重要意义。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第13期|P.5841-5844|共4页
作者
Novella IS; Duarte EA; Elena SF; Moya A; Domingo E; Holland JJ;
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作者单位

Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Evolution; RNA Viruses; Vesicular stomatitis Indiana virus genetics; Virus Diseases; 进化; RNA病毒; 病毒性疾病;

机译：Evolution;RNA Viruses;Vesicular stomatitis Indiana virus genetics;Virus Diseases;进化;RNA病毒;病毒性疾病;

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1. Efficient escape from local optima in a highly rugged fitness landscape by evolving RNA virus populations [J] . Cervera Hector, Lalic Jasna, Elena Santiago F. Proceedings of the Royal Society. Biological sciences . 2016,第1836期

机译：通过进化RNA病毒种群，在高度崎fitness的健身环境中有效地逃脱局部最优
2. Genetic variation in fitness within a clonal population of a plant RNA virus [J] . Héctor Cervera, Santiago F. Elena Virus Evolution . 2016,第1期

机译：植物RNA病毒克隆种群中适应度的遗传变异
3. Experimental Evolution of an RNA Virus in Wild Birds: Evidence for Host-Dependent Impacts on Population Structure and Competitive Fitness [J] . Nathan D. Grubaugh, Darci R. Smith, Doug E. Brackney, PLoS Pathogens . 2015,第5期

机译：野生鸟类RNA病毒的实验演变：依赖于人口结构和竞争性能的宿主依赖影响的证据
4. Finite population models of dynamic optimization with stochastically alternating fitness functions [C] . Liekens, A.M.L., ten Eikelder, Evolutionary Computation, 2003. CEC '03. The 2003 Congress on . 2003

机译：具有随机交替适应度函数的动态优化的有限种群模型
5. Superinfection fitness as a component of overall fitness for a vertebrate RNA virus. [D] . Kell, Alison M. 2013

机译：超级感染适应性是脊椎动物RNA病毒总体适应性的组成部分。
6. Exponential increases of RNA virus fitness during large population transmissions. [O] . I S Novella, E A Duarte, S F Elena, 1995

机译：大量传播期间RNA病毒适应度呈指数增长。
7. Exponential increases of RNA virus fitness during large population transmissions. [O] . Novella, I S, Duarte, E A, Elena, S F, 1995

机译：大量传播期间RNA病毒适应度呈指数增长。
8. Population of Exponentially Distributed Individual Lifespans Cannot Lead to Gompertzian or to Weibull (with Increasing Mortality Rate) Dynamics [R] . Guess, F., Witten, M. 1986

机译：指数分布的个体寿命群体不能导致Gompertzian或Weibull（具有增加的死亡率）动态

Exponential increases of RNA virus fitness during large population transmissions.

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