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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >TRANSDIFFERENTIATION OF CHICKEN EMBRYONIC CELLS INTO MUSCLE CELLS BY THE 3' UNTRANSLATED REGION OF MUSCLE TROPOMYOSIN
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TRANSDIFFERENTIATION OF CHICKEN EMBRYONIC CELLS INTO MUSCLE CELLS BY THE 3' UNTRANSLATED REGION OF MUSCLE TROPOMYOSIN

机译：肌肌球蛋白的3'未翻译区将鸡胚胎细胞转化为肌肉细胞

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摘要

Transfection with a plasmid encoding the 3' untranslated region (3' UTR) of skeletal muscle tropomyosin induces chicken embryonic fibroblasts to express skeletal tropomyosin. Such cells become spindle shaped, fuse, and express titin, a marker of striated muscle differentiation. Skeletal muscle tropomyosin and titin organize in sarcomeric arrays. When the tropomyosin 3' UTR is expressed in osteoblasts, less skeletal muscle tropomyosin is expressed, and titin expression is delayed. Some transfected osteoblasts become spindle shaped but do not fuse nor organize these proteins into sarcomeres. Transfected cells expressing muscle tropomyosin organize muscle acid nonmuscle isoforms into the same structures. Thus, the skeletal muscle tropomyosin 3' UTR induces transdifferentiation into a striated muscle phenotype in a cell-type-specific context. [References: 52]
机译：用编码骨骼肌原肌球蛋白的3'非翻译区（3'UTR）的质粒转染诱导鸡胚成纤维细胞表达骨骼原肌球蛋白。这样的细胞变成纺锤形，融合并表达titin，这是横纹肌分化的标志。骨骼肌原肌球蛋白和肌钙蛋白组织成肌节阵列。当原肌细胞中原肌球蛋白3'UTR表达时，骨骼肌原肌球蛋白表达减少，而肌动蛋白表达被延迟。一些转染的成骨细胞变成纺锤形，但不会融合或将这些蛋白质组织成肉瘤。表达肌肉原肌球蛋白的转染细胞将肌肉酸非肌肉同工型组织成相同的结构。因此，骨骼肌原肌球蛋白3'UTR在特定于细胞类型的情况下诱导转分化为横纹肌表型。 [参考：52]

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