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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >EXOGENOUS VASCULAR ENDOTHELIAL GROWTH FACTOR INDUCES MALFORMED AND HYPERFUSED VESSELS DURING EMBRYONIC NEOVASCULARIZATION
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EXOGENOUS VASCULAR ENDOTHELIAL GROWTH FACTOR INDUCES MALFORMED AND HYPERFUSED VESSELS DURING EMBRYONIC NEOVASCULARIZATION

机译：外源性血管内皮生长因子诱导胚胎性新生血管形成畸形和过度融合的血管。

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Vascular endothelial growth factor (VEGF) is a potent and specific endothelial mitogen that is able to induce angiogenesis in vivo [Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., & Ferrara, N. (1989) Science 246 1306-1309]. To determine if VEGF also influences the behavior of primordial endothelial cells, we used an in vivo vascular assay based on the de novo formation of vessels. Japanese quail embryos injected with nanomolar quantities of the 165-residue form of VEGF at the onset of vasculogenesis exhibited profoundly altered vessel development, In fact, the overall patterning of the vascular network was abnormal in all VEGF-injected embryos, The malformations were attributable to two specific endothelial cell activities: (i) inappropriate neovascularization in normally avascular areas and (ii) the unregulated, excessive fusion of vessels, In the first instance, supernumerary vessels directly linked the inflow channel of the heart to the aortic outflow channel. The second aberrant activity led to the formation of vessels with abnormally large lumens, Ultimately, unregulated vessel fusion generated massive vascular sacs that obliterated the identity of individual vessels, These observations show that exogenous VEGF has an impact on the behavior of primordial endothelial cells engaged in vasculogenesis, and they strongly suggest that endogenous VEGF is important in vascular patterning and regulation of vessel size (lumen formation). [References: 33]
机译：血管内皮生长因子（VEGF）是一种有效且特异性的内皮有丝分裂原，能够在体内诱导血管生成[Leung，DW，Cachianes，G.，Kuang，W.-J.，Goeddel，DV，＆Ferrara，N.（ 1989）Science 246 1306-1309]。为了确定VEGF是否也会影响原始内皮细胞的行为，我们使用了基于新生血管形成的体内血管测定法。日本鹌鹑胚胎在血管新生时注射了165残基纳摩尔浓度的VEGF，其血管发育发生了显着变化。实际上，所有VEGF注入的胚胎的血管网络总体格局均异常，这种畸形可归因于两种特定的内皮细胞活性：（i）在正常无血管区域的不适当的新血管形成和（ii）血管不受监管的过度融合。首先，多余的血管将心脏的流入通道直接连接到主动脉流出通道。第二种异常活动导致形成具有异常大管腔的血管，最终，不受监管的血管融合产生了巨大的血管囊，从而破坏了单个血管的身份。这些观察结果表明，外源性VEGF对参与原始血管内皮细胞行为的影响血管生成，他们强烈建议内源性VEGF在血管形成和调节血管大小（管腔形成）中很重要。 [参考：33]

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