CRYPTORCHIDISM AND HOMEOTIC TRANSFORMATIONS OF SPINAL NERVES AND VERTEBRAE IN HOXA-10 MUTANT MICE

Rijli FM.; Pellegrini M.; Dierich A.; Gruss P.; Dolle P. Chambon P.; Matyas R.

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >CRYPTORCHIDISM AND HOMEOTIC TRANSFORMATIONS OF SPINAL NERVES AND VERTEBRAE IN HOXA-10 MUTANT MICE

【24h】

CRYPTORCHIDISM AND HOMEOTIC TRANSFORMATIONS OF SPINAL NERVES AND VERTEBRAE IN HOXA-10 MUTANT MICE

机译：HOXA-10突变小鼠的脊髓和椎骨的隐睾和顺势转变

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Homozygous mice mutated by homologous recombination for the AbdB-related Hoxa-10 gene are viable but display homeotic transformations of vertebrae and lumbar spinal nerves. Mutant males exhibit unilateral or bilateral criptorchidism due to developmental abnormalities of the gubernaculum, resulting in abnormal spermatogenesis and sterility, These results reveal an important role of Hoxa-10 in patterning posterior body regions and suggest that Hox genes are involved in specifying regional identity of both segmented and nonovertly segmented structures of the developing body. [References: 16]

机译：通过与AbdB相关的Hoxa-10基因同源重组突变的纯合小鼠是可行的，但显示出椎骨和腰椎神经的同种异体转化。突变的男性由于古柏的发育异常而表现出单侧或双侧爬行畸形，从而导致异常的精子发生和不育。这些结果揭示了Hoxa-10在模式化后体区域中的重要作用，并暗示了Hox基因参与指定了两者的区域身份显影体的分段结构和非公开分段结构。 [参考：16]

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1995年第18期|p. 8185-8189|共5页
作者
Rijli FM.; Pellegrini M.; Dierich A.; Gruss P.; Dolle P. Chambon P.; Matyas R.;
展开▼
作者单位

UNIV STRASBOURG 1 COLL FRANCE INSERM CNRS INST GENET & BIOL MOLEC & CELLULAIRE BP 163 F-67404 ILLKIRCH GRAFFENSTADEN FRANCE;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Hox genes; Segmentation; Positional information; Fertility; Expression; Gene; Limb;

机译：Hox基因;片段;位置信息;生殖力;表达;基因;肢体;

相似文献

外文文献
中文文献
专利

1. Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A [J] . Lorente M, Perez C, Sanchez C, Mechanisms of Development . 2006,第4期

机译：YY1突变小鼠轴骨架的同种异型转化以及与Polycomb组基因Ring1 / Ring1A的遗传相互作用
2. Homeotic transformations reflect departure from the mammalian ‘rule of seven’ cervical vertebrae in sloths: inferences on the Hox code and morphological modularity of the mammalian neck [J] . Christine Bhmer, Eli Amson, Patrick Arnold, BMC Evolutionary Biology . 2018,第1期

机译：顺势转化反映出树懒与哺乳动物“七规则”颈椎的背离：Hox代码和哺乳动物颈部形态模块化的推论
3. Extreme selection in humans against homeotic transformations of cervical vertebrae [J] . Galis F, Van Dooren TJM, Feuth JD, Evolution: International Journal of Organic Evolution . 2006,第12期

机译：对抗颈椎同种异体转化的人类极端选择
4. Hypoxic induction of vascular endothelial growth factor is impaired in the spinal cord of the mice with mutant human SOD1 gene [C] . Isao Nagano, Tetsuro Murakami, Mito Shiote, International Symposium on Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke and Dementia . 2003

机译：血管内皮生长因子的缺氧诱导在突变人SOD1基因的小鼠的脊髓中受损
5. AXIAL CHARACTER SERIATION IN MAMMALS: AN HISTORICAL AND MORPHOLOGICAL EXPLORATION OF THE ORIGIN, DEVELOPMENT, USE, AND CURRENT COLLAPSE OF THE HOMOLOGY PARADIGM (VERTEBRAE, LOCOMOTION, HOMEOTIC, EVOLUTION, HOMINOID). [D] . FILLER, AARON GERSHON. 1986

机译：哺乳动物的轴向特征序列化：同源性范式（椎骨，运动，顺势，进化，类人猿）的起源，发展，使用和当前崩溃的历史和形态学探索。
6. Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice. [O] . F M Rijli, R Matyas, M Pellegrini, 1995

机译：Hoxa-10突变小鼠的隐睾症和脊神经和椎骨的同种异体转化。
7. Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice. [O] . Rijli, F M, Matyas, R, Pellegrini, M, 1995

机译：Hoxa-10突变小鼠的隐睾症和脊神经和椎骨的同种异体转化。

CRYPTORCHIDISM AND HOMEOTIC TRANSFORMATIONS OF SPINAL NERVES AND VERTEBRAE IN HOXA-10 MUTANT MICE

摘要

著录项

相似文献

相关主题

期刊订阅