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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >THE SITE OF ACTION OF NEURONAL ACIDIC FIBROBLAST GROWTH FACTOR IS THE ORGAN OF CORTI OF THE RAT COCHLEA
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THE SITE OF ACTION OF NEURONAL ACIDIC FIBROBLAST GROWTH FACTOR IS THE ORGAN OF CORTI OF THE RAT COCHLEA

机译：神经酸性成纤维细胞生长因子的作用部位是大鼠耳蜗皮质的器官

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摘要

Here we show that the mature cochlear neurons are a rich source of acidic fibroblast growth factor (aFGF), which is expressed in the neuronal circuitry consisting of afferent and efferent innervation. The site of action of neuronal aFGF is likely to reside in the organ of Corti, where one of the four known FGF receptor (FGFR) tyrosine kinases-namely, FGFR-3 mRNA-is expressed, Following acoustic overstimulation, known to cause damage to the organ of Corti, a rapid up-regulation of FGFR-3 is evident in this sensory epithelium, at both mRNA and protein levels. The present results provide in vivo evidence for aFGF being a sensory neuron-derived, anterogradely transported factor that may exert trophic effects on a peripheral target tissue, In this sensory system, aFGF, rather than being a neurotrophic factor, seems to promote maintenance of the integrity of the organ of Corti. In addition, aFGF, released from the traumatized nerve endings, may be one of the first signals initiating protective recovery and repair processes following damaging auditory stimuli. [References: 35]
机译：在这里，我们显示成熟的耳蜗神经元是酸性成纤维细胞生长因子（aFGF）的丰富来源，它在由传入和传出神经支配的神经元回路中表达。神经元aFGF的作用部位可能位于Corti器官中，在听觉过度刺激后，已知的四种已知FGF受体（FGFR）酪氨酸激酶之一（即FGFR-3 mRNA）被表达，可导致对在Corti的器官中，无论是在mRNA还是在蛋白质水平，FGFR-3的快速上调在该感觉上皮中都明显可见。目前的结果提供了体内的证据，表明aFGF是一种感觉神经源性，顺行转运因子，可能对周围的靶组织产生营养作用。在这种感觉系统中，aFGF而不是一种神经营养因子似乎促进了其维持。科尔蒂器官的完整性。此外，从受损的神经末梢释放的aFGF可能是在破坏听觉刺激后启动保护性恢复和修复过程的首批信号之一。 [参考：35]

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