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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >MIXING OF CONNEXINS IN GAP JUNCTION MEMBRANE CHANNELS
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MIXING OF CONNEXINS IN GAP JUNCTION MEMBRANE CHANNELS

机译：连接蛋白在间隙连接膜通道中的混合

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摘要

Gap junctions are plaque-like clusters of intercellular channels that mediate intercellular communication, Each of two adjoining cells contains a connexon unit which makes up half of the whole channel. Gap junction channels are formed from a multigene family of proteins called connexins, and different connexins may be coexpressed by a single cell type and found within the same plaque, Rodent gap junctions contain two proteins, connexins 32 and 26, Use of a scanning transmission electron microscope for mass analysis of rodent gap junction plaques and split gap junctions provided evidence consistent with a model in which the channels may be made from (i) solely connexin 26, (ii) solely connexin 32, or (iii) mixtures of connexin 26 and connexin 32 in which the two connexons are made entirely of connexin 26 and connexin 32, The different types of channels segregate into distinct domains, implying that connexon channels self-associate to give a nonrandom distribution within tissues, Since each connexin confers distinct physiological properties on its membrane channels, these results imply that the physiological properties of channels can be tailored by mixing the constituent proteins within these macromolecular structures. [References: 29]
机译：间隙连接是介导细胞间通讯的细胞间通道的斑块状簇。两个相邻细胞的每一个都包含一个连接子单元，该单元构成整个通道的一半。间隙连接通道由称为连接蛋白的蛋白质的多基因家族形成，不同的连接蛋白可能通过单个细胞类型共表达并在同一噬菌斑中发现。啮齿动物的间隙连接包含两种蛋白，连接蛋白32和26，使用扫描透射电子用于对啮齿动物间隙连接斑块和裂口连接的质量进行分析的显微镜提供了与以下模型相符的证据，在该模型中，通道可以由（i）仅连接蛋白26，（ii）仅连接蛋白32或（iii）连接蛋白26和连接蛋白32，其中两个连接蛋白完全由连接蛋白26和连接蛋白32组成，不同类型的通道分离为不同的域，这意味着连接蛋白通道自缔合，从而在组织内产生非随机分布，因为每种连接蛋白均赋予其独特的生理特性这些结果暗示可以通过将成分蛋白与在这些大分子结构中。 [参考：29]

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