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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >MAINTENANCE OF PRE-MRNA SECONDARY STRUCTURE BY EPISTATIC SELECTION
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MAINTENANCE OF PRE-MRNA SECONDARY STRUCTURE BY EPISTATIC SELECTION

机译：静电选择维持前mRNA二级结构

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Linkage disequilibrium between polymorphisms in a natural population may result from various evolutionary forces, including random genetic drift due to sampling of gametes during reproduction, restricted migration between subpopulations in a subdivided population, or epistatic selection, In this report, we present evidence that the majority of significant linkage disequilibria observed in introns of the alcohol dehydrogenase locus (Adh) of Drosophila pseudoobscura are due to epistatic selection maintaining secondary structure of precursor mRNA (pre-mRNA). Based on phylogenetic-comparative analysis and a likelihood approach, we propose secondary structure models of Adh pre mRNA for the regions of the adult intron and intron 2 where clustering of linkage disequilibria has been observed, Furthermore, we applied the likelihood ratio test to the phylogenetically predicted secondary structure in intron 1. In contrast to the other two structures, polymorphisms associated with the more conserved stem-loop structure of intron 1 are in low frequency, and linkage disequilibria have not been observed, These findings are qualitatively consistent with a model of compensatory fitness interactions, This model assumes that mutations disrupting pairing in a secondary structural element are individually deleterious if they destabilize a functionally important structure; a second ''compensatory'' mutation, however, may restabilize the structure and restore fitness. [References: 30]
机译：自然种群中多态性之间的连锁不平衡可能是由各种进化力造成的，包括由于生殖过程中配子的采样而导致的随机遗传漂移，再细分种群中亚种群之间的迁移受限或上位性选择。在本报告中，我们提供了证据，表明大多数果蝇果蝇的乙醇脱氢酶基因座（Adh）内含子中观察到的显着连锁不平衡的原因是由于上位性选择维持了前体mRNA（pre-mRNA）的二级结构。基于系统发育比较分析和似然方法，我们针对成年内含子和内含子2区域中观察到连锁不平衡现象的区域，提出了Adh pre mRNA的二级结构模型，此外，我们将似然比检验应用于系统发育内含子1的预测二级结构。与其他两个结构相比，与内含子1的茎环结构更保守相关的多态性处于较低频率，并且未观察到连锁不平衡，这些发现在质量上与A的模型相符。补偿适应性相互作用，该模型假设破坏二级结构元件中的配对的突变如果使功能上重要的结构不稳定，则它们个体有害。但是，第二个“补偿性”突变可能会使结构恢复稳定并恢复适应性。 [参考：30]

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