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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Receptor-induced polymerization of coatomer
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Receptor-induced polymerization of coatomer

机译：受体诱导的涂料聚合

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摘要

Coatomer, the coat protein complex of COPl vesicles, is involved in the budding of these vesicles, but the underlying mechanism is unknown. Toward a better under- standing of this process, the interaction between coatomer and the cytoplasmic domain of a major transmembrane protein of COPI vesicles, p23, was studied. Interaction of coatomer with this peptide domain results in a conformational change and polymerization of the complex in viyro. This changed confor- mation also is observed in vivo, i.e., on the surface of authentic, isolated COPI vesicles. An average of four peptides was found associated with one coatomer complex after polymerization. Based on these results, we propose a mechanism by which the induced conformational change of coatomer results in its polymerization, and thus drives formation of the bud on tbe Golgi membrane during biogenesis of a COPI vesicle.
机译：Coatomer是COP1囊泡的外壳蛋白复合物，参与这些囊泡的出芽，但其潜在机制尚不清楚。为了更好地理解这一过程，研究了涂层蛋白与COPI囊泡主要跨膜蛋白p23的胞质域之间的相互作用。涂层剂与该肽结构域的相互作用导致构象变化和复合体在紫胶中的聚合。在体内，即在真实的，分离的COPI囊泡表面也观察到了这种改变的构象。聚合后，平均发现四种肽与一种涂料复合物有关。基于这些结果，我们提出了一种机制，通过该机制，涂层剂的诱导构象变化导致其聚合，从而在COPI囊泡的生物发生过程中驱动tbe高尔基膜上芽的形成。

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