Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly Pathway in Saccharomyces cerevisuae

BRENT A. ALTHEIM; MICHAEL C. SCHUTZ

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Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly Pathway in Saccharomyces cerevisuae

机译：组蛋白修饰控制酿酒酵母中复制无关的染色质组装途径的细胞周期调控

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We describe a replication-independent, cell cycle-regulated chromatin assembly pathway in budding yeast. The activity of this pathway is low in S phase extracts but is very high in G2, M, and G1 cell extracts, with peak activity in late M/early G1. The cell cycle regulation of this pathway requires a specific pattern of posttranslational mod- ification of histones H3 and/or H4, which is distinct for H3/H4 present in S phase versus M and G1 phase cell extracts. Histone H3/H4 modification is therefore important for the reciprocal control of replication-dependent and -independent chromatin assembly pathways during the cell cycle.

机译：我们描述了在发芽酵母中的复制独立，细胞周期调节的染色质组装途径。在S期提取物中，该途径的活性较低，但在G2，M和G1细胞提取物中，该途径的活性很高，在晚期M /早期G1中具有最高活性。该途径的细胞周期调控需要组蛋白H3和/或H4的翻译后修饰的特定模式，这对于S期中的H3 / H4与M和G1期细胞提取物而言是不同的。因此，组蛋白H3 / H4修饰对于细胞周期中复制依赖性和非依赖性染色质组装途径的相互控制很重要。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1999年第4期|1345-1350|共6页
作者
BRENT A. ALTHEIM; MICHAEL C. SCHUTZ;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres [J] . Peter W. Lewis, Simon J. Elsaesser, Kyung-Min Noh, Proceedings of the National Academy of Sciences of the United States of America . 2010,第32期

机译：Daxx是一种H3.3特异的组蛋白伴侣，可与ATRX一起在端粒上复制独立的染色质组装中
2. The histone variant h3.3 marks active chromatin by replication-independent nucleosome assembly. [J] . Ahmad K, Henikoff S Molecular cell . 2002,第6期

机译：组蛋白变体h3.3通过不依赖复制的核小体装配来标记活性染色质。
3. Regulation of histone modification and chromatin structure by the p53–PADI4 pathway [J] . Chizu Tanikawa, Martha Espinosa, Akari Suzuki, Nature Communications . 2012,第2016期

机译：通过p53–PADI4途径调节组蛋白修饰和染色质结构
4. Systems level analysis of histone H3 post-translational modifications reveals features of PTM crosstalk in chromatin regulation [C] . Veit Schwammle, Simone Sidoli, Chrystian Ruminowicz, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：组蛋白H3后翻译后修饰的系统水平分析显示了染色质调节中PTM串扰的特征
5. Modification of histone H4 promotes centromere protein-A nucleosome assembly: Molecular mechanisms of centromeric chromatin assembly. [D] . Godek, Kristina M. 2010

机译：组蛋白H4的修饰促进着丝粒蛋白A核小体装配：着丝粒染色质装配的分子机制。
6. Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly pathway in Saccharomyces cerevisiae [O] . Brent A. Altheim, Michael C. Schultz 1999

机译：组蛋白修饰控制细胞的细胞周期调节依赖复制的染色质组装途径酿酒酵母
7. Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly pathway in Saccharomyces cerevisiae [O] . Altheim, Brent A., Schultz, Michael C. 1999

机译：组蛋白修饰控制细胞的细胞周期调节依赖复制的染色质组装途径酿酒酵母
8. Dynamics of Post-Translational Modifications on Human Histone H4 Through the Cell Cycle [R] . Bullock, C. R. 2006

机译：人组蛋白H4通过细胞周期的翻译后修饰动力学

Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly Pathway in Saccharomyces cerevisuae

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