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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity
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Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity

机译：成年大脑保留产生具有广泛髓鞘形成能力的少突胶质祖细胞的潜力

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摘要

Remyelination of focal areas of the central nervous system (CNS) in animals can be achieved by trans- plantation of glial cells, yet the source of these cells in humans to similarly treat myelin disorders is limited at present to fetal tissue. Multipotent precursor cells are present in the CNS of adult as well as embryonic and neonatal animals and can differentiate into lineage-restricted progenitors such as oli. godendroglial progenitors (OPs). The OPs present in adults have a different phenotype from those seen in earlier life, and their potential role in CNS repair remains unknown. To gain insights into the potential to manipulate the myelinating capacity of these precursor and/or Progenitor cells, we gen- erated a homogenous culture of OPs from neural precursor cells isolated from adult rat subependymal tissues. Phenotypic characterization indicated that these OPs resembled neonatal rather than adult OPs and produced robust myelin after transplantation. The ability to generate such cells from the adult brain therefore opens an avenue to explore the potential of these cells for repairing myelin disorders in adulthood.
机译：可以通过移植神经胶质细胞来实现动物中枢神经系统（CNS）焦点区域的髓鞘再生，但是目前这些细胞在人类中以类似方式治疗髓鞘疾病的来源仅限于胎儿组织。多能性前体细胞存在于成年动物以及胚胎和新生动物的中枢神经系统中，并且可以分化成谱系受限的祖细胞，例如oli。 Godendroglial祖细胞（OPs）。成人中存在的OP具有与早期生命不同的表型，其在中枢神经系统修复中的潜在作用仍然未知。为了深入了解操纵这些前体和/或祖细胞的髓鞘形成能力的潜力，我们从从成年大鼠表皮下组织分离的神经前体细胞中生成了OP的均质培养物。表型特征表明，这些OP类似于新生儿而非成人OP，并且在移植后产生坚固的髓磷脂。因此，从成年大脑中产生此类细胞的能力为探索这些细胞修复成年期髓鞘疾病的潜力开辟了一条途径。

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