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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Horizontal gene iransfer among genomes: The complexity hypothesis
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Horizontal gene iransfer among genomes: The complexity hypothesis

机译：基因组间水平基因转移：复杂性假设

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Increasingly, studies or genes and genomes are indicating that considerable horizontal transfer has occurred between prokaryotcs. Extensive horizontal transfer has occurred for operational genes (those involved in housekeeping), whereas informational genes (those involved in transcription, translation, and related processes) are seldmly horizontally transferred. Through phylogenctic analy- Sis of six complete prokaryotic genomes and the identification of 312 sets or orthologous genes present in all six genomesi, we tested two theories describing the temporal flow of horizontal trensfer. We show that operational genes have been horizon. tally transferred continuously since the divergence of the prokaryotes, rather than having been exchanged in one, or a few, massive events that occurred early in the evolution of prokaryotes. In agreement with earlier studies, we found that differences in rates of evolution between operational and informational genes are minimal, suggesting that factors other than rate of evolution are responsible for the observed differ- ences in horizontal transfer. We propose that a major factor in the more frequent horizontal transfer of operational genes is that informational genes are typically members of large, complex systems, whereas operational genes are not, thereby making horizontal transfer of informational gene products
机译：越来越多的研究或基因和基因组表明原核生物之间发生了相当大的水平转移。可操作基因（涉及管家的基因）发生了广泛的水平转移，而信息基因（涉及转录，翻译和相关过程的基因）则被水平转移。通过对六个完整原核基因组的系统进化分析以及对所有六个基因组中存在的312个直系同源基因的鉴定，我们测试了描述水平横行时间流的两种理论。我们证明了可操作基因已经成为地平线。自从原核生物发散以来，计数一直在连续转移，而不是交换成原核生物演化初期发生的一个或几个大规模事件。与早期研究一致，我们发现操作基因和信息基因之间的进化速率差异很小，这表明除进化速率以外的其他因素也可引起水平转移的差异。我们认为，操作基因更频繁水平转移的一个主要因素是信息基因通常是大型，复杂系统的成员，而操作基因则不是，从而使信息基因产物水平转移

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