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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity
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Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity

机译：人CD16作为介导直接自然杀伤细胞细胞毒性的裂解受体

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摘要

In addition to their role in peptide antigen presentation, class I MHC proteins also play a critical role in inhibiting natural killer (NK) cytotoxicity through interaction with NK inhibitory receptors. Thus, NK cells are cytotoxic to virus-infected and tumor cells that have lost class I MHC protein expression. However, the nature of the receptors involved in the triggering of lysis of target cells is poorly understood. CD16 (Fcr receptor lll) has been described as a receptor expressed on NK cells that facilitates antibody-dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. However, we show here that CD16 has a broader function and is directly involved in the lysis of some virus-infected cell and tumor cells, independent of antibody binding. The presence of a putative CD16 ligand on appropriate target cells has also been demonstrated by the use of a CD16-Ig fusion protein.
机译：除了在肽抗原呈递中的作用外，I类MHC蛋白还通过与NK抑制受体相互作用而在抑制自然杀伤（NK）细胞毒性中发挥关键作用。因此，NK细胞对已感染I类MHC蛋白表达的病毒感染和肿瘤细胞具有细胞毒性。然而，对于触发靶细胞裂解的受体的性质了解甚少。 CD16（Fcr受体III）已被描述为在NK细胞上表达的受体，其通过与各种抗体的Fc部分结合而促进抗体依赖性细胞毒性（ADCC）。但是，我们在这里显示CD16具有更广泛的功能，并且直接参与某些病毒感染的细胞和肿瘤细胞的裂解，而与抗体结合无关。通过使用CD16-Ig融合蛋白也已经证明在适当的靶细胞上存在推定的CD16配体。

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