Continuation of neurogenesis in the hippocampus of the adult macaque monkey

DAVID R. KORNACK; PASKO RAKIC

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Continuation of neurogenesis in the hippocampus of the adult macaque monkey

机译：成年猕猴海马中神经发生的持续

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摘要

We present evidence for continuous generation of neurons, oligodendrocytes, and astrocytes in the hippocampal dentate gyrus of adult macaque monkeys, using immunohistochemical double labeling for bromodeoxyuridine and cell-type- specific markers. We estimate that the relative rate of neurogenesis is approximately 10 times less than that reported in the adult rodent dentate gyrus. Nevertheless, the generation of these three cell types in a discreet brain region suggests that a multipotent neural stem cell may be retained in the adult primate hippocampus. This demonstration of adult neurogenesis in nonhuman old World primateswith their phylogenetic proximity to humans, long life spans, and elaborate cognitive abilities establishes the macaque as an unexcelled animal model to experimentally investigate issues of neurogenesis in humans and offers new insights into its significance in the adult brain.

机译：我们提供了成年猕猴海马齿状回中连续生成神经元，少突胶质细胞和星形胶质细胞的证据，使用了溴脱氧尿嘧啶核苷和细胞类型特异性标记物的免疫组织化学双重标记。我们估计，神经发生的相对速率比成年啮齿动物齿状回所报道的相对速率低约10倍。然而，在谨慎的大脑区域中这三种细胞类型的产生表明，多能神经干细胞可能保留在成年灵长类海马体中。非人类的旧世界灵长类动物的成年神经发生的证明及其与人类的亲缘关系，寿命长，以及精巧的认知能力，使猕猴成为了一种出色的动物模型，可以通过实验研究人类的神经发生问题，并提供了对其在成年中的意义的新见解。脑。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1999年第10期|5768-5773|共6页
作者
DAVID R. KORNACK; PASKO RAKIC;
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作者单位

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
neurobiology; neurogenesis; hippocampus; macaque monkey;

机译：神经生物学神经发生海马猕猴;

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1. Hormones and the regulation of adult neurogenesis in the hippocampus and beyond: Where are we now? Introduction to the special issue on hormonal regulation of adult neurogenesis: Implications for disease [J] . Galea Liisa A. M., Duarte-Guterman Paula Frontiers in neuroendocrinology . 2016,第Null期

机译：激素和海马及其他地方的成人神经发生的调控：我们现在在哪里？关于成人神经发生激素调节的特殊问题简介：对疾病的影响
2. Hormones and the regulation of adult neurogenesis in the hippocampus and beyond: Where are we now? Introduction to the special issue on hormonal regulation of adult neurogenesis: Implications for disease [J] . Galea Liisa A. M., Duarte-Guterman Paula Frontiers in neuroendocrinology . 2016,第Null期

机译：激素和海马和超越成人神经发生的调节：我们现在在哪里？成人神经发生激素调节特殊问题介绍：疾病的影响
3. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. [J] . Lee J, Duan W, Mattson MP Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2002,第6期

机译：有证据表明，脑源性神经营养因子是基础神经发生所必需的，并且在一定程度上介导了成年小鼠海马中通过饮食限制来促进神经发生。
4. 5.6: Presentation session: Neuroscience informatics: “Genetic analysis of BDNF expression cliques and adult neurogenesis in the hippocampus” [C] . Mulligan Megan K. Proceedings of the 2010 Biomedical Sciences and Engineering Conference . 2010

机译：5.6：演讲环节：神经科学信息学：“ BDNF表达集团的基因分析和海马的成年神经发生”
5. The dentate gyrus of the hippocampus: roles of transforming growth factor beta1 (TGFbeta1) and adult neurogenesis in the expression of spatial memory. [D] . Martinez Canabal, Alonso. 2013

机译：海马齿状回：转化生长因子β1（TGFbeta1）和成人神经发生在空间记忆表达中的作用。
6. Continuation of neurogenesis in the hippocampus of the adult macaque monkey [O] . David R. Kornack, Pasko Rakic 1999

机译：成年猕猴海马中神经发生的持续
7. Continuation of neurogenesis in the hippocampus of the adult macaque monkey [O] . Kornack, David R., Rakic, Pasko 1999

机译：成年猕猴海马中神经发生的持续

Continuation of neurogenesis in the hippocampus of the adult macaque monkey

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