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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A brain sexual dimorphism controlled by adult circulating androgens
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A brain sexual dimorphism controlled by adult circulating androgens

机译：由成人循环雄激素控制的大脑性二态性

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摘要

Reports of structural differences between the brains of men and women, heterosexual and homosexual men, and male-to-female transsexuals and other men have been offered as evidence that the behavioral differences between these groups are likely caused by differences in the early development of the brain. However, a possible confounding variable is the concentration of circulating hormones seen in these groups in adulthood. Evaluation of this possibility hinges on the extent to which circulating hormones can alter the size of mammalian brain regions as revealed by Nissl stains. We now report a sexual dimorphism in the volume of a brain nucleus in rats that can be completely accounted for by adult sex differences in circulating androgen. The pos- terodorsal nucleus of the medial amygdala (MePD) has a greater volume in male rats than in females, but adult castration of males causes the volume to shrink to female values within four weeks, whereas androgen treatment of adult females for that period enlarges the MePD to levels equivalent to normal males. This report demonstrates that adult hor- mone manipulations can completely reverse a sexual dimor- phism in brain regional volume in a mammalian species. The sex difference and androgen responsiveness of MePD volume is reflected in the soma size of neurons there.
机译：男性，女性，异性恋和同性恋者以及男性至女性的变性者和其他男性的大脑之间的结构差异的报告已被提供，以证明这些群体之间的行为差​​异可能是由人类早期发育的差异引起的。脑。但是，可能的混淆变量是成年后这些人群中所见的循环激素浓度。如Nissl染色所示，对这种可能性的评估取决于循环激素可在多大程度上改变哺乳动物大脑区域的大小。现在，我们报告了大鼠脑核体积的性二态性，这可以完全由循环雄激素的成年性别差异来解释。雄性大鼠的杏仁核内侧后核（MePD）的体积比雌性大鼠大，但是成年雄性去势使雌性大鼠在四个星期内缩小为雌性值，而雄性激素在该时期的雄性激素治疗则扩大了MePD的水平相当于正常男性。该报告表明，成年激素的操纵可以完全逆转哺乳动物物种的大脑区域容积中的性二型性。 MePD体积的性别差异和雄激素反应性反映在该处神经元的体细胞大小上。

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