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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Somatic Stiffness of cochlear outer hair cells is voltage-dependent
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Somatic Stiffness of cochlear outer hair cells is voltage-dependent

机译：耳蜗外毛细胞的体细胞刚度取决于电压

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摘要

The mammalian cochlea depends on an amplification process for its sensitivity and frequency-resolving capability. Outer hair cells are responsible for providing this amplification. It is usually assumed that the membrane-potential-driven somatic shape changes of these cells are the basis of the amplifying process, It is of interest to see whether mechanical reactance changes of the cells might accompany their changes in cell shape. We now show that the cylindrical outer hair cells change their axial stiffness as their membrane potential is altered. Cell stiffness was determined by optoelectronically measuring the amplitude of motion of a flexible vibrating fiber as it was loaded by the isolated cell. Voltage commands to the cell were delivered in a tight-seal whole-cell configuration. Cell stiffness was decreased by depolarization and increased by hyperpolarization.
机译：哺乳动物的耳蜗的敏感性和频率分辨能力取决于扩增过程。外毛细胞负责提供这种扩增。通常假设这些细胞的膜电位驱动的体细胞形状变化是扩增过程的基础。有趣的是，观察细胞的机械电抗变化是否可能伴随其细胞形状变化。现在我们显示，圆柱形外毛细胞随着其膜电位的改变而改变其轴向刚度。电池刚度是通过光电测量柔性振动纤维在被隔离的电池加载时的运动幅度来确定的。电池的电压命令以密封的全电池配置传递。细胞的刚度因去极化而降低，而因超极化而增加。

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