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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >High gene density is conserved at syntenic loci of small and large grass genomes
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High gene density is conserved at syntenic loci of small and large grass genomes

机译：高基因密度在大小草基因组的同位基因座上均保守

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Comparative genomic analysis at the geneticmap level has shown extensive conservation of the gene order between the different grass genomes in many chromosomal regions. However, little is known about the gene organization in grass genomes at the microlevel. Comparison of genecoding regions between maize, rice, and sorphum showed that the distance between the genes is correlated with the genome size. We have investigated the microcolinearity at Lrk gene loci in the genomes of four grass species: wheat, barley, maize, and rice. The Lrk genes, which encode receptor-like kinases, were found to be consistently associated with another type of recentor-like kinase (Tak) on chromosome groups 1 and 3 in Triticeae and on chromosomes homoeologous to Triticeae group 3 in the other grass genomes. On Triticeae chromosome group 1, Tak and Lrk together with genes putatively encoding NBS/LRR proteins form a cluster of genes possibly involved in signal transduction. Comparison of the gene composition at orthologous Lrk loci in wheat, barley, and rice revealed a maximal gene density of one gene per 4-5kb, very similar to the gene density in Arabidopsis thaliana. We conclude that small and large grass genomes contain regions that are highly enriched in genes with very little or no repetitive DNA. The comparison of the gene organization suggested various genome rearrangements during the evolution of the different grass species.
机译：基因图水平的比较基因组分析表明，在许多染色体区域中，不同草基因组之间的基因顺序具有广泛的保守性。但是，关于草基因组中的基因组织的微观水平知之甚少。玉米，水稻和马铃薯的基因编码区的比较表明，基因之间的距离与基因组大小有关。我们已经研究了四种草种（小麦，大麦，玉米和水稻）的Lrk基因位点的微共线性。发现编码受体样激酶的Lrk基因与黑麦属的第1和3号染色体组以及与其他草基因组中与黑麦属的第3组同源的染色体上的另一种类型的最近性样激酶（Tak）一致相关。在小麦的第1组染色体上，Tak和Lrk与假定编码NBS / LRR蛋白的基因一起形成了可能与信号转导有关的基因簇。比较小麦，大麦和水稻直系同源Lrk基因座的基因组成，发现最大基因密度为每4-5kb一个基因，与拟南芥中的基因密度非常相似。我们得出的结论是，大大小小的草类基因组包含的区域高度富含很少或没有重复DNA的基因。基因组织的比较表明在不同草种进化过程中各种基因组重排。

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