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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes
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Heterophile antibodies segregate in families and are associated with protection from type 1 diabetes

机译：嗜异性抗体在家族中分离并与1型糖尿病的预防相关

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摘要

Markedly elevated levels of serum IL-4 were reported previously in 50 of a small group of type 1 diabetes nonprogessors. To determine the patterns of expression for this phenotype, a larger cohort of 58 families containing type 1 diabetic patients was examined. Analysis of the two-site ELISA assay used to measure serum IL-4 revealed evidence for heterophile antibodies, i.e., nonanalyte substances in serum capable of binding antibodies mutivalently and providing erroneous analyte (e.g.,IL-4) quantification. Interestingly, relatives without type 1 diabetes were significantly more likely to have this phenotype than were patients with the disease (p=0.003). In addition, the trait appears to have clustered within certain families and was associated with the protective MHC allele DQB1*0602 (p=0.008). These results suggest that heterophile antibodies represent an in vivo trait associated with self-tolerance and nonprogression to diabetes.
机译：先前在少数1型1型糖尿病患者中报告了血清IL-4的水平显着升高。为了确定该表型的表达模式，检查了包含58型1型糖尿病患者的较大家庭。用于测量血清IL-4的两点ELISA测定法的分析揭示了亲脂抗体的证据，即，血清中能够与抗体多价结合并提供错误分析物（例如IL-4）定量的非分析物。有趣的是，没有1型糖尿病的亲戚比患有该疾病的患者更容易出现这种表型（p = 0.003）。此外，该性状似乎在某些家族中聚集，并且与保护性MHC等位基因DQB1 * 0602相关（p = 0.008）。这些结果表明，嗜异性抗体代表与自我耐受性和糖尿病进展无关的体内特征。

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