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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption
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Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption

机译：骨桥蛋白缺陷型小鼠对卵巢切除术诱导的骨吸收有抵抗力

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摘要

Osteopontin is one of the major noncollagenous bone matrix proteins produced by osteoblasts and osteoclasts, bone cells that are uniquely responsible for the remodeling of mineralized tissues. Osteoclasts express the αvβ3 integrin, which is one of the receptors for osteopontin. Recent knockout studies revealed that noncollagenous bone matrix proteins are functionally important in regulation of bone metabolism. However, the significance of the presence of osteopontin in vivo has not been known. We report here that osteopontin knockout mice are resistant to ovariectomy-induced bone resorption compared with wild-type mice. Mi-crocomputed tomography analysis indicated about 60 reduction in bone volume by ovariectomy in wild-type mice, whereas the osteopontin-deficient mice exhibited only about 10 reduction in trabecular bone volume after ovariectomy. Reduction in uterine weight was observed similarly in both wild-type and osteopontin-deficient mice, indicating the specificity of the effect of osteopontin deficiency on bone metabolism. We propose that osteopontin is essential for postmenopausal osteoporosis in women. Strategies to counteract osteopontin's action may prove effective in suppressing osteoporosis.
机译：骨桥蛋白是由成骨细胞和破骨细胞产生的主要非胶原骨基质蛋白之一，成骨细胞和破骨细胞是唯一负责矿化组织重塑的骨细胞。破骨细胞表达αvβ3整联蛋白，它是骨桥蛋白的受体之一。最近的基因敲除研究表明，非胶原骨基质蛋白在调节骨代谢中功能上很重要。但是，体内骨桥蛋白存在的重要性尚不清楚。我们在这里报告，与野生型小鼠相比，骨桥蛋白基因敲除小鼠对卵巢切除术诱导的骨吸收具有抗性。微型计算机断层扫描分析表明，在野生型小鼠中，卵巢切除术可减少约60骨体积，而骨桥蛋白缺陷型小鼠在卵巢切除术后的骨小梁仅可减少约10骨体积。在野生型和骨桥蛋白缺陷型小鼠中，子宫重量的减少均类似地观察到，表明骨桥蛋白缺陷对骨代谢的影响具有特异性。我们建议骨桥蛋白对于女性绝经后骨质疏松症至关重要。抵消骨桥蛋白作用的策略可能被证明可以有效地抑制骨质疏松症。

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