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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord
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Brain-derived neurotrophic factor is an endogenous modulator of nociceptive responses in the spinal cord

机译：脑源性神经营养因子是脊髓伤害感受反应的内源性调节剂

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摘要

The primary sensory neurons that respond to noxious stimulation and project to the spinal cord are known to fall into two distinct groups: one sensitive to nerve growth factor and the other sensitive to glial cell-line-derived neurotrophic factor. There is currently considerable interest in the ways in which these factors may regulate nociceptor properties. Recently, however, it has emerged that another trophic factor-brain-derived neurotrophic factor (BDNF)-may play an important neuromodulatory role in the dorsal born of the spinal cord. BDNF meets many of the criteria necessary to establish it as a neurotransmittereuromodulator in small-diameter nociceptive neurons. It is synthesized by these neurons and packaged in dense core vesicles in nociceptor terminals in the superficial dorsal horn. It is markedly up-regulated in inflammatory conditions in a nerve growth factor-dependent fashion. Postsynaptic cells in this region express receptors for BDNF. Spinal neurons show increased excitability to nociceptive inputs after treatment with exogenous BDNF. There are both electrophysiological and behavioral data showing that antagonism of BDNF at least partially prevents some aspects of central sensitization. Together, These findings suggest that BDNF may be released from primary sensory nociceptors with activity, particularly in some persistent pain states, and may then increase the excitability of rostrally projecting second-order systems. BDNF released from nociceptive terminals may thus contribute to the sensory abnormalities associated with some pathophysiological states, n
机译：已知对有害刺激产生反应并投射到脊髓的主要感觉神经元可分为两个不同的组：一个对神经生长因子敏感，另一个对神经胶质细胞系衍生的神经营养因子敏感。目前，人们对这些因素调节伤害感受器特性的方式非常感兴趣。然而，最近发现，另一种营养因子-脑源性神经营养因子（BDNF）-可能在脊髓背侧出生中起重要的神经调节作用。 BDNF符合在小直径伤害感受性神经元中将其确立为神经递质/神经调节剂所必需的许多标准。它是由这些神经元合成的，并包装在浅表背角伤害感受器末端的密集核心小泡中。在炎症条件下，它以神经生长因子依赖性方式显着上调。该区域中的突触后细胞表达BDNF的受体。在用外源性BDNF治疗后，脊髓神经元对伤害性输入的兴奋性增加。电生理和行为数据均表明，BDNF的拮抗作用至少部分阻止了中枢敏化的某些方面。在一起，这些发现表明BDNF可能会从具有活动的初级感觉伤害感受器中释放出来，尤其是在某些持续性疼痛状态下，然后可能会增加投射于第二级系统的兴奋性。从伤害性末端释放的BDNF可能因此导致与某些病理生理状态相关的感觉异常，n

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