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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum
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Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum

机译：Rifins：在恶性疟原虫感染的红细胞表面表达的第二个克隆变异蛋白家族

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摘要

Many pathogens evade the host immune response or adapt to their environment By expressing surface proteins that undergo rapid switching. In the case of ptasmo- Jium falciparum, products of a multigene family known as var are expressed on the surface of infected red cells, where they undergo clonal antigenic variation and contribute to malaria pathogenesis by mediating adhesion to a variety of host endothelial receptors and to uninfected red blood cells by forming rosettes. Herein we show that a second gene family, rif, which is associated with var at subtelomeric sites in the genome, encodes clonally variant proteins (rifins) that are expressed on the infected red cell surface. Their high copy number, sequence variability, and red cell surface location indicate an important role for rifins in malaria host-parasite interaction.
机译：许多病原体通过表达经历快速转换的表面蛋白来逃避宿主的免疫反应或适应其环境。就恶性疟原虫而言，称为var的多基因家族的产物在受感染的红细胞表面表达，它们在其中经历克隆性抗原变异，并通过介导对多种宿主内皮受体和细胞黏附的介导而促进疟疾发病。通过形成玫瑰花结而未感染的红细胞。在本文中，我们显示了第二个基因家族rif，与基因组中亚端粒位点处的var相关，编码在感染的红细胞表面表达的克隆变异蛋白（rifins）。它们的高拷贝数，序列变异性和红细胞表面位置表明，利福平在疟疾宿主-寄生虫相互作用中具有重要作用。

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