...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae
【24h】

Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae

机译：通过固定相可促进酿酒酵母的复制衰老

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sacchuromyces cerevisiae mother cells undergo an aging program that includes morphologic changes, sterility, redistribution of the Sir transcriptional silencing complex from HM loci and telomeres to the nucleolus, alterations in nucleolar architecture, and accumulation of extra chromosomal ribosomal DNA circles (ERCs). We report here that cells starved for nutrients during prolonged periods in stationary phase show a decrease in generational lifespan when they reenter the cell cycle. This shortened lifespan is not transmitted to progeny cells, indicating that it is not due to irreversible genetic damage. The decrease in the lifespan is accompanied hy all of the changes of accclerated aging with the notable exception that ERC accumulation is not atigmented compared with generation-matched, nonstarved cells. These results suggest a number of models, including one in which starvation reveals a component of aging that works in parallel with the accumulation of ERCs. Stationary-phase yeast cells may be a useful system for identifying factors that affect aging in other nondividing eukaryotic cells.
机译：酿酒酵母母细胞经历衰老程序，包括形态变化，不育性，Sir转录沉默复合物从HM位点和端粒到核仁的重新分布，核仁结构的改变以及多余的染色体核糖体DNA环（ERC）的积累。我们在这里报告，细胞长期处于营养缺乏状态而缺乏营养，当它们重新进入细胞周期时，其寿命会缩短。缩短的寿命没有传递给后代细胞，表明它不是由于不可逆转的遗传损伤。寿命的减少伴随着全衰老的变化，值得注意的例外是与世代匹配的非饥饿细胞相比，ERC的积累没有减少。这些结果表明存在许多模型，其中一个模型显示饥饿与ERC的积累同时发挥作用。静止期酵母细胞可能是一个有用的系统，用于识别影响其他非分裂真核细胞衰老的因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号