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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cytomegalovirus-encoded β chemokine promotes monocyte-associated viremia in the host
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Cytomegalovirus-encoded β chemokine promotes monocyte-associated viremia in the host

机译：巨细胞病毒编码的β趋化因子促进宿主单核细胞相关病毒血症

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摘要

Chemokine homologs are encoded by many large DNA viruses, suggesting that they contribute to control of host leukocyte transmigration and trafficking during viral infection. Murine cytomegalovirus carries a CC (β) chemokine homolog gene giving rise to two related proteins, murine cytomegalovirus chemokine 1 and 2 (MCK-1 and MCK-2). MCK-1 peptide was found to induce calcium signaling and adherence in murine peritoneal macrophages. Cells bearing human chemokine receptor CCR3 and the human macro-phage THP1 cell line were responsive to MCK-1. This pattern suggested that MCK-1 might act as an agonist, promoting leukocyte trafficking during viral infection. Consistent with this prediction, MCK-1/MCK-2 mutant viruses exhibit dramatically reduced peak levels of monocyte-associated viremia in experimentally infected mice. Thus, MCK-1/MCK-2 appears to promote host leukocyte migration to initial sites of infection and may be responsible for attracting monocytes or macrophages that efficiently disseminate virus in the host.
机译：趋化因子同源物由许多大型DNA病毒编码，表明它们在病毒感染期间有助于控制宿主白细胞的迁移和运输。鼠巨细胞病毒携带CC（β）趋化因子同源基因，产生两个相关蛋白，鼠巨细胞病毒趋化因子1和2（MCK-1和MCK-2）。发现MCK-1肽在鼠腹膜巨噬细胞中诱导钙信号传导和粘附。带有人趋化因子受体CCR3和人巨噬细胞THP1细胞系的细胞对MCK-1有反应。这种模式表明MCK-1可能起激动剂的作用，在病毒感染期间促进白细胞运输。与此预测一致，MCK-1 / MCK-2突变病毒在实验感染的小鼠中显示出单核细胞相关病毒血症峰值水平显着降低。因此，MCK-1 / MCK-2似乎促进宿主白细胞迁移到感染的初始部位，并且可能负责吸引单核细胞或巨噬细胞，从而有效地在宿主体内传播病毒。

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