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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Virulence of antibiotic-resistant Salmonella typhimurium
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Virulence of antibiotic-resistant Salmonella typhimurium

机译：耐药性鼠伤寒沙门氏菌的毒力

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摘要

We show that most Salmonella typhimurium mutants resistant to streptomycin, rifampicin, and nalidixic acid are avirulent in mice. Of seven resistant mutants exam- ined, six were avirulent and one was similar to the wild type in competition experiments in mice. The avirulent-resistant mutants rapidly accumulated various types of compensatory mutations that restored virulence without concomitant loss of resistance. Such second-site compensatory mutations were more common then reversion to the sensitive wild type. We infer from these results that a reduction in the use of antibiotics might not result in the disappearance of the resistant bacteria already present in human and environmen- tal reservoirs.
机译：我们显示大多数对链霉素，利福平和萘啶酸有抗性的鼠伤寒沙门氏菌突变体在小鼠中无毒。在老鼠的竞争实验中，检查了七个抗性突变体，其中六个是无毒的，一个类似于野生型。无毒抗性的突变体迅速积累了各种类型的补偿性突变，这些突变可恢复毒力而不会随之丧失抗性。这种第二位代偿性突变更常见，然后又恢复为敏感的野生型。从这些结果我们可以推断，减少抗生素的使用可能不会导致人类和环境库中已经存在的抗药性细菌消失。

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