MEKK1 activates both IκB kinase α and IκB kinase β

Frank S. Lee; Robert T. Peters; Luan C. Dang

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MEKK1 activates both IκB kinase α and IκB kinase β

机译：MEKK1激活IκB激酶α和IκB激酶β

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A critical step in the signal-induced activa- tion of the transcription factor NF-κB is the site-specific phosphorylation of its inhibitor, IκB, that targets the latter for degradation by the ubiquitin-proteasome pathway. We have previously shown that mitogen-activated protein kinase/ERK kinase kinase 1 (MEKK1) can induce both this site-specific phosphorylation of IκBα at Ser-32 and Ser-36 in vivo and the activity of a high molecular weight IκB kinase complex in vitro. Subsequently, others have identified two proteins, IκB kinase α (IKK-α) and IκB kinase β (IKK-β), that are present in a tumor necrosis factor α-inducible, high molecular weight IκB kinase complex.

机译：信号诱导转录因子NF-κB激活的关键步骤是其抑制剂IκB的位点特异性磷酸化，该酶靶向后者通过泛素-蛋白酶体途径降解。先前我们已经证明，丝裂原激活的蛋白激酶/ ERK激酶激酶1（MEKK1）可以在体内诱导Ser-32和Ser-36处IκBα的这种位点特异性磷酸化，并在体内诱导高分子量IκB激酶复合物的活性。体外。随后，其他人鉴定了两种蛋白，IκB激酶α（IKK-α）和IκB激酶β（IKK-β），它们存在于肿瘤坏死因子α诱导的高分子量IκB激酶复合物中。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1998年第16期|p.9319-9324|共6页
作者
Frank S. Lee; Robert T. Peters; Luan C. Dang;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Activation of p21-CDC42/Rac-activated kinases by CD28 signaling: p21-activated kinase (PAK) and MEK kinase 1 (MEKK1) may mediate the interplay between CD3 and CD28 signals (published erratum appears in J Immunol 1999 Mar 1;162(5):3104) [J] . Kaga S, Ragg S, Rogers KA, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第9期

机译：CD21信号激活p21-CDC42 / Rac激活的激酶：p21激活的激酶（PAK）和MEK激酶1（MEKK1）可能介导CD3和CD28信号之间的相互作用（已发表的勘误表见J Immunol 1999 Mar 1; 162（ 5）：3104）
2. Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2 [J] . Deborah N. Chadee, Takashi Yuasa, John M. Kyriakis Molecular and Cellular Biology . 2002,第3期

机译：Ste20p同源GCK和衔接蛋白TRAF2直接激活丝裂原活化的蛋白激酶激酶MEKK1。
3. Novel Phosphorylation-dependent Ubiquitination of Tristetraprolin by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase Kinase 1 (MEKK1) and Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2) [J] . Yvonne Schichl, Ulrike Resch, Christof Lemberger, The Journal of biological chemistry . 2011,第44期

机译：通过促丝裂解蛋白激酶/细胞外信号调节激酶激酶激酶激酶激酶激酶激酶激酶激酶激酶激酶激酶激酶激酶激酶激酶激酶1（MEKK1）和肿瘤坏死因子受体相关因子2（TRAF2）的新型磷酸化依赖性
4. Activation of Mitogen-activated Protein Kinases and Protein Kinase B/akt Signaling By Oxidative Stress in Vascular Smooth Muscle Cells: involvement in Vascular Pathophysiology [C] . Ashok K. Srivastava, Nihar R. Pandey, Antoine Blanc International Society for Heart Research.Congress . 2004

机译：血管平滑肌细胞氧化应激激活丝裂剂活化蛋白激酶和蛋白激酶B / Akt信号传导：血管病理生理学中的参与
5. The role of mitogen activated protein kinase activated protein kinase-2 in regulating p38 mitogen activated protein kinase induced cyclooxygenase-2 induction and heart failure. [D] . Streicher, John Michael. 2009

机译：促分裂原激活蛋白激酶激活蛋白激酶2在调节p38促分裂原激活蛋白激酶诱导的环氧合酶2和心力衰竭中的作用。
6. Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2 [O] . Deborah N. Chadee, Takashi Yuasa, John M. Kyriakis 2002

机译：Ste20p同源GCK和衔接蛋白TRAF2直接激活丝裂原活化的蛋白激酶激酶MEKK1。
7. Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein TRAF2 [O] . Chadee, Deborah N., Yuasa, Takashi, Kyriakis, John M. 2002

机译：Ste20p同源GCK和衔接蛋白TRAF2直接激活丝裂原活化的蛋白激酶激酶MEKK1。

MEKK1 activates both IκB kinase α and IκB kinase β

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