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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum
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Phospholipase Cβ4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum

机译：磷脂酶Cβ4特别参与发育中小脑的攀爬纤维突触消除

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摘要

Elimination of excess climbing fiber (CF)- Purkinje cell synapses during cerebellar development involves a signaling pathway that includes type 1 metabotropic gluta- mate receptor, G_αq, and the γ isoform of protein kinase C. To identify phospholipase C (PLC) isoforms involved in this process, we generated mice deficient in PLCβ4, one of two major isoforms expressed in Purkinje cells. PLCβ4 mutant mice are viable but exhibit locomotor ataxia. Their cerebellar histology, parallel fiber synapse formation, and basic electro- physiology appear normal. However, developmental elimina- tion of multiple CF innervation clearly is impaired in the rostral portion of the cerebellar vermis, in which PLCβ4 mRNA is predominantly expressed.
机译：在小脑发育过程中消除多余的攀爬纤维（CF）-浦肯野细胞突触涉及一个信号通路，该信号通路包括1型代谢型谷氨酸受体G_αq和蛋白激酶C的γ亚型。鉴定参与的磷脂酶C（PLC）亚型在这个过程中，我们产生了PLCβ4缺陷的小鼠，PLCβ4是Purkinje细胞表达的两种主要同工型之一。 PLCβ4突变小鼠是可行的，但表现出运动性共济失调。他们的小脑组织学，平行纤维突触的形成和基本的电生理学看来是正常的。然而，在主要表达PLCβ4mRNA的小脑ver的延髓部，明显消除了多个CF神经支配的发育消除。

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