Anti-β2 glycoprotein I (β2GPI) autoantibodies recognize an epitope on the first domain of β2GPI

G. Michael Iverson; Edward J. Victoria; David M. Marquis

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Anti-β2 glycoprotein I (β2GPI) autoantibodies recognize an epitope on the first domain of β2GPI

【24h】

Anti-β2 glycoprotein I (β2GPI) autoantibodies recognize an epitope on the first domain of β2GPI

机译：抗β2糖蛋白I（β2GPI）自身抗体识别β2GPI第一个结构域上的表位

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Anticardiolipin (aCL) autoantibodies are as- sociated with thrombosis, recurrent fetal loss, and thrombo- cytopenia. Only aCL found in autoimmune disease require the participation of the phospholipid binding plasma protein β2 glycoprotein I (?2GPI) for antibody binding and now are called anti-β2GPI. The antigenic specificity of aCL affinity purified from 11 patients with high titers was evaluated in an effort to better understand the pathophysiology associated with aCL. Seven different recombinant domain-deleted mu- tants of human β2GPI, and full length human β2GPI (wild- type), were used in competition assays to inhibit the autoan- tibodies from binding to immobilized wild-type β2GPI.

机译：抗心磷脂（aCL）自身抗体与血栓形成，反复胎儿丢失和血小板减少症相关。只有在自身免疫性疾病中发现的aCL才需要磷脂结合血浆蛋白β2糖蛋白I（β2GPI）参与抗体结合，现在被称为抗β2GPI。为了更好地了解与aCL相关的病理生理，对从11位高滴度的患者中纯化的aCL亲和力的抗原特异性进行了评估。在竞争分析中使用了7种不同的重组人β2GPI缺失结构域的突变体和全长人类β2GPI（野生型），以抑制自身抗体与固定的野生型β2GPI结合。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1998年第26期|p.15542-15546|共5页
作者
G. Michael Iverson; Edward J. Victoria; David M. Marquis;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Target Recognition of β2-Glycoprotein I (β2GPI)-Dependent Anticardiolipin Antibodies: Evidence for Involvement of the Fourth Domain of β2GPI in Antibody Binding [J] . Jacob George, Boris Gilburd, Maja Hojnik, The journal of immunology . 1998,第8期

机译：β2-糖蛋白I（β2GPI）依赖的抗心磷脂抗体的目标识别：参与抗体结合的β2GPI第四域的证据。
2. Platelet-associated anti-glycoprotein (GP) IIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura mainly recognize cation-dependent conformations: comparison with the epitopes of serum autoantibodies. [J] . Kosugi S, Tomiyama Y, Shiraga M, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 1996,第2期

机译：慢性免疫性血小板减少性紫癜中的血小板相关抗糖蛋白（GP）IIb-IIIa自身抗体主要识别阳离子依赖性构象：与血清自身抗体的表位比较。
3. Antigenic Epitopes on Human P-glycoprotein Recognized by Autoimmune Hepatitis Autoantibody as a Case Study [J] . Masatoshi Masuda, Takaharu Mizutani Journal of health science. . 2007,第3期

机译：自身免疫性肝炎自身抗体识别的人P-糖蛋白抗原表位作为案例研究
4. Human p2-Glycoprotein I Binds To Endothelial Cells Through A Cluster of Lysihe Residues that Are Critical for Anionic Phospholipid Binding and Offers Epitopes for Anti- p2-Glycoprotein I Antibodies [C] . Del Papa N, Sheng YH, Raschi E, NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：人P2-糖蛋白I通过对阴离子磷脂结合至关重要的Lysihe残基团结合内皮细胞，并为抗P2-糖蛋白I抗体提供表位
5. Antibody responses of horses to five major glycoproteins of equine herpesvirus 1 and specificity of responses to antigenic domains of glycoproteins B and C. [D] . Ostlund, Eileen Noel. 1992

机译：马对马疱疹病毒1的5种主要糖蛋白的抗体应答以及对糖蛋白B和C抗原域的应答的特异性。
6. Anti-β2 glycoprotein I (β2GPI) autoantibodies recognize an epitope on the first domain of β2GPI [O] . G. Michael Iverson, Edward J. Victoria, David M. Marquis 1998

机译：抗β2糖蛋白I（β2GPI）自身抗体识别β2GPI第一个结构域上的表位
7. Antigenic Epitopes on Human P-glycoprotein Recognized by Autoimmune Hepatitis Autoantibody as a Case Study [O] . Masatoshi Masuda, Takaharu Mizutani 2007

机译：自身免疫性肝炎自身抗体识别人对人对糖蛋白的抗原表位作为案例研究

Anti-β2 glycoprotein I (β2GPI) autoantibodies recognize an epitope on the first domain of β2GPI

摘要

著录项

相似文献

相关主题

期刊订阅